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Showing 1–11 of 11 results
Advanced filters: Author: Carolin Seuring Clear advanced filters

  • The solid-state NMR structure of an amyloid fiber formed by human hormone β-endorphin reveals a protonated Glu8 in the fibrillar core. Under neutral conditions, deprotonation of Glu8 would contribute to fibril disassembly and hormone peptide release.

    • Carolin Seuring
    • Joeri Verasdonck
    • Roland Riek
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 1178-1184

  • The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.

    • Carolin Seuring
    • Kartik Ayyer
    • Henry N. Chapman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Here, the authors report de novo design, optimization and characterization of tRNAs that decode UGA stop codons in E. coli. The structure of the ribosome in a complex with the designed tRNA bound to a UGA stop codon suggests that distinct A-site ligands (tRNAs versus release factors) induce distinct conformation of the stop codon within the mRNA in the decoding center.

    • Suki Albers
    • Bertrand Beckert
    • Zoya Ignatova
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Free-electron lasers are capable of high repetition rates and it is assumed that protein crystals often do not survive the first X-ray pulse. Here the authors address these issues with a demonstration of multi-hit serial crystallography in which multiple FEL pulses interact with the sample without destroying it.

    • Susannah Holmes
    • Henry J. Kirkwood
    • Connie Darmanin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • XFEL radiation is providing new opportunities for probing biological systems. Here the authors perform nanoscale x-ray imaging of microtubules with helical symmetry, by using imaging sorting and reconstruction techniques.

    • Gisela Brändén
    • Greger Hammarin
    • Richard Neutze
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure.

    • Max O. Wiedorn
    • Dominik Oberthür
    • Anton Barty
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11