The role of neddylatin in inflammatory arthritis is not well understood. Here we reveal that NEDD8 and CULLIN-1 are significantly upregulated in the synovium of patients with RA. Neddylation activation is crucial for the pathobiology of collagen-induced arthritis. Mechanistically, TRAF6 neddylation at Lys124 is essential for IL-17A-induced NF-κB activation in synoviocytes.
- Kewei Liu
- Kaizhe Chen
- Changwei Li