There are two main pathways to rid a cell from accumulated protein misfits, the ubiquitin-proteasome system and autophagy. When the ubiquitin proteasome system breaks down, as is the case in a fly model for neurodegenerative disease, autophagy is able to compensate for this loss. HDAC6, a microtubule-associated-histone deacetlyase that interacts with polyubiquitinated proteins, seems to be the link.
- Udai Bhan Pandey
- Zhiping Nie
- J. Paul Taylor
