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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deubiquitinating enzyme, USP3.

Zsuzsanna Nagy
Janith A. Seneviratne
Glenn M. Marshall
ResearchOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1-20
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.

Pei Y. Liu
Andrew E. Tee
Tao Liu
ResearchOpen Access05 Nov 2019
Nature Communications

Volume: 10, P: 1-17
An evolutionary continuum from nucleated dwarf galaxies to star clusters

In the Virgo galaxy cluster, we identified a continuum of objects that maps the morphological transition between nucleated dwarf galaxies and ultra-compact dwarf galaxies (UCDs), providing evidence for the formation of UCDs through tidal stripping of ancient dwarf galaxies.

Kaixiang Wang
Eric W. Peng
Mingcheng Zhu
Research08 Nov 2023
Nature

Volume: 623, P: 296-300
Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis

A chemical mutagenesis screen identifies RNF121 as an oncogenic cofactor for MYCN in neuroblastoma.

Belamy B. Cheung
Ritu Mittra
Glenn M. Marshall
ResearchOpen Access14 Oct 2024
Communications Biology

Volume: 7, P: 1-13
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

Alice Salib
Nisitha Jayatilleke
Glenn M. Marshall
ResearchOpen Access04 Dec 2023
Oncogene

Volume: 43, P: 363-377

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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

An evolutionary continuum from nucleated dwarf galaxies to star clusters

Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis

MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

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