Mice that cannot sense glucose with their pro-opiomelanocortin (POMC neurons) develop glucose intolerance, demonstrating that glucose sensing in neurons plays an important role in responding to a systemic glucose load. It is also shown that in mice with obesity-induced type 2 diabetes, glucose-sensing by POMC neurons is defective.
- Laura E. Parton
- Chian Ping Ye
- Bradford B. Lowell