Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression is upregulated in MC3T3-E1 cells cultured in osteogenic medium. MALAT1 acts as a miR-494 sponge to activate specificity protein 1(SP1)/Toll-like receptor 2/bone morphogenetic protein 2 signaling axis. Knockdown of MALAT1 or overexpression of miR-494 inhibits osteogenic differentiation and angiogenesis. Overexpression of SP1 or inhibition of miR-494 reverses the regulatory of sh-MALAT1 on osteogenic differentiation and angiogenesis in MC3T3-E1.
- Ao Ding
- Cheng-Hua Li
- Zhi-Hong Zhang
