The burden of herpes simplex virus (HSV) infection is exacerbated due to the emergence of antiviral drug resistance and a lack of effective antibodies. Here the authors construct a bispecific nanobody that blocks receptor binding and prevents gD-gH/gL interaction, and show that it protects against HSV-1 and HSV-2 infection in mice.
- Jing Hu
- Haoyuan Tan
- Tengchuan Jin
