In nature, terpenes are made by forming isoprene chains and then folding the chains into carbocycles, followed by oxidation and rearrangement reactions. Now, inspired by nature, a range of polycyclic terpene structures are synthesized from phenols through a three-step sequence of prenylation, dearomatization and/or prenyl migration, and then epoxidation and/or radical cyclization. Several total syntheses of natural products are carried out using this approach.
- Farbod Salahi
- Chengbo Yao
- Scott A. Snyder