Drug-encapsulated nanoparticles (NPs) are emerging as therapeutic agents to deliver DNA\drugs into cells. However, clinical applications demand a technique to concentrate NPs at the diseased cells that are beneath other tissues. We report a strategy to achieve this goal with magnetic- and therapeutic NP-coated microbubbles as carriers. Although external magnetic field concentrates them at the targeted tissue, moderate ultrasound irradiation at their resonance frequency drives stable oscillation and microstreaming flow. Consequently, the NP armor detaches, penetrates into tissues and is later internalized by the cells. This technique would greatly improve the on-target delivery of nanomedicine, thereby reduces cost and side effects.
- Yu Gao
- Chon U Chan
- Chenjie Xu
