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Showing 1–17 of 17 results
Advanced filters: Author: Chenxiang Lin Clear advanced filters

  • Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

    • Congmin Zhu
    • Linwei Wu
    • Jizhong Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • A DNA origami nanodevice presents its hidden death ligand pattern in the acidic tumour microenvironment to kill cancerous cells, opening opportunities for effective and safe cancer therapy.

    • Kun Zhou
    • Chenxiang Lin
    News & Views
    Nature Nanotechnology
    Volume: 19, P: 1765-1766

  • By using nuclear pore complex mimics, the authors demonstrate that the cytoplasm-facing Nup358 provides a dock for the HIV-1 capsid, and the nucleoplasm-facing Nup153 positions the capsid for NPC entry. Nup358 and Nup153 thus create an affinity gradient which regulates capsid penetration, whereas Nup62 constitutes a final NPC gatekeeper against HIV-1 capsid entry.

    • Qi Shen
    • Qingzhou Feng
    • Yong Xiong
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 425-435

  • Small liposomes of uniform sizes are valuable tools for studying membrane biology and developing drug-delivery vehicles. Now, a DNA-assisted sorting technique has been shown to produce multiple species of monodispersed liposomes with mean diameters below 150 nm in a scalable manner. This approach has enabled the high-resolution analyses of curvature-dependent membrane protein activities.

    • Yang Yang
    • Zhenyong Wu
    • Chenxiang Lin
    Research
    Nature Chemistry
    Volume: 13, P: 335-342

  • Use of DNA-origami nanostructures to study lipid transfer between closely apposed membrane bilayers supports a model where phospholipids are transferred by extended synaptotagmin 1 between the endoplasmic reticulum and plasma membrane through a shuttle mechanism.

    • Xin Bian
    • Zhao Zhang
    • Chenxiang Lin
    Research
    Nature Chemical Biology
    Volume: 15, P: 830-837

  • Controlling liposome shape, arrangement and dynamics is important for biophysical studies and synthetic biology applications. Now, using a family of reconfigurable DNA nanocages as templates, spherical, tubular, toroidal and helical liposomes with predefined geometry have been produced. DNA-guided membrane fusion and bending is also demonstrated.

    • Zhao Zhang
    • Yang Yang
    • Chenxiang Lin
    Research
    Nature Chemistry
    Volume: 9, P: 653-659

  • Precise control of vesicle size is highly desirable both for basic biochemical research and biomedical applications. Now, monodispersed sub-100-nm vesicles with predefined sizes have been produced using a method based on membrane self-assembly within a DNA-nanostructure guide.

    • Yang Yang
    • Jing Wang
    • Chenxiang Lin
    Research
    Nature Chemistry
    Volume: 8, P: 476-483

  • Enzymatic reactions can be coupled together by carefully organizing the enzymes on DNA scaffolds.

    • Chenxiang Lin
    • Hao Yan
    News & Views
    Nature Nanotechnology
    Volume: 4, P: 211-212

  • Here the authors show that Omicron neutralizing antibody titers decline over time in mice immunized with a wild-type (WT) lipid nanoparticle (LNP)-mRNA vaccine and are robustly increased by WT or Omicron LNP-mRNA and that Omicron boosters elicit higher BA.1-neutralizing titer than WT boosters.

    • Zhenhao Fang
    • Lei Peng
    • Sidi Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.

    • Qi Shen
    • Chenxiang Lin
    News & Views
    Nature Chemistry
    Volume: 12, P: 221-222

  • Life-science research and biomedical diagnostics call for robust fluorescence barcodes of compact size and high multiplexing capability. Here DNA-origami technology was used to construct a new kind of geometrically encoded barcode with excellent structural stiffness. They hold promise for both in situ and ex situ imaging of diverse biologically relevant entities.

    • Chenxiang Lin
    • Ralf Jungmann
    • Peng Yin
    Research
    Nature Chemistry
    Volume: 4, P: 832-839

  • A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

    • Xuyang Ning
    • Abdusalam Abdukerim
    • Yubo Zhou
    Research
    Nature
    Volume: 618, P: 47-50

  • Dey et al. discuss the design and implementation of DNA origami, as well as the techniques used to analyse quality and construction. They summarize exciting new research areas where DNA nanotechnology is being used and future directions for the field.

    • Swarup Dey
    • Chunhai Fan
    • Pengfei Zhan
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-24