Nature Search

Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Single-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show a convergent signature with psychopathology across multiple cell types.

Anna S. Fröhlich
Nathalie Gerstner
Elisabeth B. Binder
ResearchOpen Access03 Sept 2024
Nature Neuroscience

Volume: 27, P: 2021-2032
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

P: 1-11
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Author Correction: Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning

Kenneth M. McCullough
Chris Chatzinakos
Kerry J. Ressler
Amendments and CorrectionsOpen Access27 Oct 2020
Nature Communications

Volume: 11, P: 1
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Genetic architecture distinguishes tinnitus from hearing loss

The genetic basis of tinnitus and how it relates to hearing loss genetics is unknown. In a large GWAS for tinnitus, the authors discover tinnitus’ distinct genetic architecture from hearing loss and its correlation with a spectrum of psychiatric disorders.

Royce E. Clifford
Adam X. Maihofer
Caroline M. Nievergelt
ResearchOpen Access19 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning

Fear and fear extinction learning are dynamic. These dynamic changes are underlined by transcriptional changes. Here, the authors translationally profiled Crh neurons in the amygdala and and identified relevant gene networks.

Kenneth M. McCullough
Chris Chatzinakos
Kerry J. Ressler
ResearchOpen Access14 Oct 2020
Nature Communications

Volume: 11, P: 1-11
GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk

Chris Chatzinakos
Foivos Georgiadis
Nikolaos P. Daskalakis
Research01 Sept 2020
Neuropsychopharmacology

Volume: 46, P: 255-256
Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes

Nikolaos P. Daskalakis
Changxin Xu
Rachel Yehuda
Research10 Nov 2020
Neuropsychopharmacology

Volume: 46, P: 763-773

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Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Fine-mapping genomic loci refines bipolar disorder risk genes

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Genomics yields biological and phenotypic insights into bipolar disorder

Author Correction: Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Genetic architecture distinguishes tinnitus from hearing loss

Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning

GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk

Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes

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