Nature Search

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Tumor diagnosis recharacterization enabled by comprehensive genomic profiling to guide precision medicine strategy

Ann Carr
Jennifer B. Jackson
Robert Auber
ResearchOpen Access21 May 2025
npj Precision Oncology

Volume: 9, P: 1-9
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
The biogeographic differentiation of algal microbiomes in the upper ocean from pole to pole

Latitudinal ecosystem boundaries in the global upper ocean may be driven by many factors. Here the authors investigate pole-to-pole eukaryotic phytoplankton metatranscriptomes, gene co-expression networks, and beta diversity, finding that geographic patterns are best explained by temperature gradients.

Kara Martin
Katrin Schmidt
Thomas Mock
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer’s disease

Jesus Campagna
Sujyoti Chandra
Varghese John
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Comparison of Gastric Alimetry^® body surface gastric mapping versus electrogastrography spectral analysis

Gabriel Schamberg
Stefan Calder
Armen A. Gharibans
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
The role of zinc in the adaptive evolution of polar phytoplankton

Polar microalgae have high zinc demand. Here, the authors use quantitative proteomics and transcriptomics of polar and non-polar model algae combined with cellular physiology to show that zinc plays an important role in supporting photosynthetic growth in eukaryotic polar phytoplankton.

Naihao Ye
Wentao Han
Thomas Mock
Research02 Jun 2022
Nature Ecology & Evolution

Volume: 6, P: 965-978
CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Prevalence and architecture of de novo mutations in developmental disorders

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Jeremy F. McRae
Stephen Clayton
Matthew E. Hurles
Research25 Jan 2017
Nature

Volume: 542, P: 433-438
Digital twins for the era of personalized surgery

Yosra Magdi Mekki
Gijs Luijten
Mitchell A. Stotland
ReviewsOpen Access15 May 2025
npj Digital Medicine

Volume: 8, P: 1-8
Coassembly and binning of a twenty-year metagenomic time-series from Lake Mendota

Tiffany Oliver
Neha Varghese
Emiley A. Eloe-Fadrosh
ResearchOpen Access04 Sept 2024
Scientific Data

Volume: 11, P: 1-7
Artificial intelligence in surgery

This Review outlines the state of the art of artificial intelligence in the preoperative, intraoperative and postoperative settings, where it has enormous potential to improve patient outcomes, surgical education and system efficiencies.

Chris Varghese
Ewen M. Harrison
Eric J. Topol
Reviews13 May 2024
Nature Medicine

Volume: 30, P: 1257-1268
A genomic catalog of Earth’s microbiomes

Cataloging microbial genomes from Earth’s environments expands the known phylogenetic diversity of bacteria and archaea.

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
ResearchOpen Access09 Nov 2020
Nature Biotechnology

Volume: 39, P: 499-509
Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.

Rekha Seshadri
Sinead C Leahy
William J Kelly
ResearchOpen Access19 Mar 2018
Nature Biotechnology

Volume: 36, P: 359-367
Comparative Microarray Analysis of Gene Expression During Activation of Human Peripheral Blood T Cells and Leukemic Jurkat T Cells

Zhaosheng Lin
G Chris Fillmore
Megan S Lim
Research01 Jun 2003
Laboratory Investigation

Volume: 83, P: 765-776
Author Correction: CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access01 Apr 2021
Nature Biotechnology

Volume: 39, P: 521
Publisher Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access18 Nov 2020
Nature Biotechnology

Volume: 39, P: 520
Metagenomes and metatranscriptomes from boreal potential and actual acid sulfate soil materials

Eva Högfors-Rönnholm
Margarita Lopez-Fernandez
Mark Dopson
ResearchOpen Access16 Oct 2019
Scientific Data

Volume: 6, P: 1-6
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Rita Alaggio
Catalina Amador
Wei-Li Zhao
Amendments and CorrectionsOpen Access19 Jul 2023
Leukemia

Volume: 37, P: 1944-1951
Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta

A novel assay quantifies depolarization of synaptosomes from Alzheimer’s cortex, and the authors show that tau released from these samples is unphosphorylated and C-terminal-truncated. Most tau is exosomal, and free-floating tau did not seed aggregation. Seeding activity was lower in tauopathy than AD, and strongly related to amyloid level.

Emily Miyoshi
Tina Bilousova
Karen Hoppens Gylys
ResearchOpen Access30 Aug 2021
Laboratory Investigation

Volume: 101, P: 1605-1617
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

Jesus Campagna
Patricia Spilman
Varghese John
ResearchOpen Access04 Dec 2018
Scientific Reports

Volume: 8, P: 1-15
Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis

G Swaminathan
C A Cartwright
Research20 Jun 2011
Oncogene

Volume: 31, P: 376-389
Microbial metagenomes and metatranscriptomes during a coastal phytoplankton bloom

Brent Nowinski
Christa B. Smith
Mary Ann Moran
ResearchOpen Access22 Jul 2019
Scientific Data

Volume: 6, P: 1-7
Microbiomes of Velloziaceae from phosphorus-impoverished soils of the campos rupestres, a biodiversity hotspot

Antonio Pedro Camargo
Rafael Soares Correa de Souza
Rafael Silva Oliveira
ResearchOpen Access31 Jul 2019
Scientific Data

Volume: 6, P: 1-11
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Mapping the human genetic architecture of COVID-19

Tumor diagnosis recharacterization enabled by comprehensive genomic profiling to guide precision medicine strategy

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

The biogeographic differentiation of algal microbiomes in the upper ocean from pole to pole

Genetic mechanisms of critical illness in COVID-19

Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer’s disease

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Comparison of Gastric Alimetry^® body surface gastric mapping versus electrogastrography spectral analysis

The role of zinc in the adaptive evolution of polar phytoplankton

CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Prevalence and architecture of de novo mutations in developmental disorders

Digital twins for the era of personalized surgery

Coassembly and binning of a twenty-year metagenomic time-series from Lake Mendota

Artificial intelligence in surgery

A genomic catalog of Earth’s microbiomes

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Comparative Microarray Analysis of Gene Expression During Activation of Human Peripheral Blood T Cells and Leukemic Jurkat T Cells

Author Correction: CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Author Correction: CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Author Correction: A genomic catalog of Earth’s microbiomes

Publisher Correction: A genomic catalog of Earth’s microbiomes

Metagenomes and metatranscriptomes from boreal potential and actual acid sulfate soil materials

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis

Microbial metagenomes and metatranscriptomes during a coastal phytoplankton bloom

Microbiomes of Velloziaceae from phosphorus-impoverished soils of the campos rupestres, a biodiversity hotspot

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Search

Quick links

Search

Filter By:

Search

Quick links