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Showing 1–8 of 8 results
Advanced filters: Author: Christin Herrmann Clear advanced filters

  • Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial antiviral responses leading to viral clearance.

    • Christin Herrmann
    • Kimberly Zaldana
    • Ken Cadwell
    Research
    Nature Microbiology
    P: 1-14

  • Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression.

    • Yonghe Wu
    • Michael Fletcher
    • Bernhard Radlwimmer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Adenovirus produces two early proteins, E1B55K and E4orf6, that become components of the host cell ubiquitin ligase complex comprising elongin-B and C, cullin-5 and RBX1. The authors identified new protein substrates that are ubiquitinated by the E1B55K–E4orf6 complex and find that hnRNP-C and RALY play an inhibitory role on late viral RNA transcripts and that this is counteracted by ubiquitination due to a reduction on the capacity of these proteins to interact with viral RNA.

    • Christin Herrmann
    • Joseph M. Dybas
    • Matthew D. Weitzman
    Research
    Nature Microbiology
    Volume: 5, P: 1217-1231

  • Here, a small core protein of human adenoviruses is shown to associate with histones, sequestering proteins on host chromatin and preventing inflammatory proteins from being released and triggering inflammation.

    • Daphne C. Avgousti
    • Christin Herrmann
    • Matthew D. Weitzman
    Research
    Nature
    Volume: 535, P: 173-177

  • In mice with Eµ-myc transgenic lymphomas in which therapy-induced senescence (TIS) depends on the H3K9 histone methyltransferase Suv39h1, TIS-competent lymphomas but not TIS-incompetent Suv39h1– lymphomas show increased glucose utilization and ATP production after senescence-inducing chemotherapy to cope with proteotoxic stress elicited by factors of the senescence-associated secretory phenotype (SASP); senescent cancers are selectively vulnerable to drugs that block glucose utilization or autophagy.

    • Jan R. Dörr
    • Yong Yu
    • Clemens A. Schmitt
    Research
    Nature
    Volume: 501, P: 421-425

  • Martin Brandt et al. studied foliage mass from Senegal over 30 years, observing the effects of climate change on dryland vegetation. Rainfall caused increases in both herbaceous and woody foliage, but woody vegetation benefits from rainfall timing changes with potential knock-on effects to the local herbivore populations.

    • Martin Brandt
    • Pierre Hiernaux
    • Rasmus Fensholt
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10