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Showing 1–23 of 23 results

Advanced filters: Author: Christine Lochner Clear advanced filters

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

P: 1-11
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Author Correction: Obsessive–compulsive disorder

Dan J. Stein
Daniel L. C. Costa
H. Blair Simpson
Amendments and Corrections16 Oct 2024
Nature Reviews Disease Primers

Volume: 10, P: 1
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

The study performed on a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.

Willem B. Bruin
Paul Zhutovsky
Moji Aghajani
Research10 Jan 2024
Nature Mental Health

Volume: 2, P: 104-118
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Cees J. Weeland
Selina Kasprzak
Chris Vriend
ResearchOpen Access21 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-10
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
ResearchOpen Access02 May 2023
Molecular Psychiatry

Volume: 28, P: 4307-4319
A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease

Max A. Laansma
Yuji Zhao
Boris A. Gutman
ResearchOpen Access19 Nov 2024
npj Parkinson's Disease

Volume: 10, P: 1-13
A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease

Conor Owens-Walton
Talia M. Nir
Ysbrand van der Werf
ResearchOpen Access11 Aug 2024
npj Parkinson's Disease

Volume: 10, P: 1-12
Obsessive–compulsive disorder

This Primer by Stein and colleagues discusses the epidemiology, mechanisms, diagnosis and treatment of obsessive–compulsive disorder, which is a psychiatric disorder that is characterized by the presence of obsessions and compulsions.

Dan J. Stein
Daniel L. C. Costa
H. Blair Simpson
Reviews01 Aug 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-21
Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Willem B. Bruin
Luke Taylor
Guido A. van Wingen
ResearchOpen Access08 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-12
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
ResearchOpen Access07 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1063-1074
Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure

Chris Vriend
Niels T. de Joode
Odile A. van den Heuvel
ResearchOpen Access16 Jan 2024
Molecular Psychiatry

Volume: 29, P: 1033-1045
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Nynke A. Groenewold
Janna Marie Bas-Hoogendam
Nic J. A. Van der Wee
Research19 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1079-1089
White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

Fabrizio Piras
Federica Piras
Gianfranco Spalletta
ResearchOpen Access17 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

Mary Mufford
Josh Cheung
Dan J. Stein
ResearchOpen Access22 Mar 2019
Translational Psychiatry

Volume: 9, P: 1-10
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
Amendments and CorrectionsOpen Access07 Mar 2024
Molecular Psychiatry

Volume: 29, P: 1216
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

Paul D Arnold
Kathleen D Askland
Gwyneth Zai
Research01 Aug 2017
Molecular Psychiatry

Volume: 23, P: 1181-1188
Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
Amendments and CorrectionsOpen Access15 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4320
Expanding the heuristic neurocircuit-based taxonomy to guide treatment for OCD: reply to the commentary “Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder”

Elizabeth Shephard
Emily R. Stern
Euripedes C. Miguel
Correspondence03 Jun 2022
Molecular Psychiatry

Volume: 27, P: 3560-3561
Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder

Christie L. Burton
Mathieu Lemire
Paul D. Arnold
ResearchOpen Access02 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-10
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder

Elizabeth Shephard
Emily R. Stern
Euripedes C. Miguel
Reviews07 Jan 2021
Molecular Psychiatry

Volume: 26, P: 4583-4604