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Showing 1–28 of 28 results
Advanced filters: Author: Christoph Wanner Clear advanced filters

  • Although renal dysfunction can have a profound effect on the pathogenesis of cardiovascular disease, current guidelines for the management of hyperlipidemia in patients with chronic kidney disease (CKD) were formulated in the absence of data on cardiovascular and cerebrovascular outcomes in this population. Considering the individual stages of CKD, authors from the University of Würzburg, Germany, analyze data from the 4D trial and other studies, and attempt to answer the question of when hyperlipidemia should (or should not) be treated in patients with CKD.

    • Vera Krane
    • Christoph Wanner
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 2, P: 176-177

  • Inflammation is highly prevalent in patients with chronic kidney disease (CKD) and is associated with increased mortality and cardiovascular events. Besides reducing lipid levels, statins have anti-inflammatory effects that are modified by the presence of inflammation, making these agents especially effective in patients with CKD who show evidence of inflammation and raised levels of C-reactive protein. In this Review, Krane and Wanner provide an overview of statin studies in patients with CKD, and discuss how the results could influence clinical decision making.

    • Vera Krane
    • Christoph Wanner
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 385-397

  • In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4 mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

    • Ellen M. Apperloo
    • Jose L. Gorriz
    • Hiddo J. L. Heerspink
    Research
    Nature Medicine
    Volume: 31, P: 278-285

  • In this Review, participants in the 7thInternational Fabry Nephropathy Roundtable, which was convened in Barcelona, Spain in June 2007, propose guidelines and recommendations for the diagnosis and management of Fabry nephropathy in adults. The roles of enzyme replacement and antiproteinuric therapy are emphasized. The authors suggest that these organ-specific recommendations could have a greater impact on clinical practice than general Fabry disease guidelines.

    • Alberto Ortiz
    • João P Oliveira
    • David G Warnock
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 327-336

  • A new study by Chang et al. reports that coronary artery bypass grafting (CABG) may be preferable to percutaneous coronary intervention (PCI) for multivessel coronary revascularization in appropriately selected patients on maintenance dialysis.

    • Christoph Wanner
    • Kitty J. Jager
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 197-198

  • Statins reduce the risk of atherosclerotic vascular disease in healthy individuals and those with chronic kidney disease (CKD); however, clinical trials have suggested a minimal effect of statins on CKD progression. The PLANET trials compared the renal effects of rosuvastatin and atorvastatin, but the findings leave many questions unanswered.

    • Richard Haynes
    • Christoph Wanner
    News & Views
    Nature Reviews Nephrology
    Volume: 11, P: 262-263

  • Palaeoclimate temperature records are dominated by Northern Hemisphere reconstructions. This study introduces a new Southern Hemisphere millennial temperature reconstruction from terrestrial and oceanic proxy records. This highlights the asynchronicity of temperature fluctuations across the two hemispheres, which should be taken into consideration in climate models and projections.

    • Raphael Neukom
    • Joëlle Gergis
    • David Frank
    Research
    Nature Climate Change
    Volume: 4, P: 362-367

  • Recent analyses from the FIELD randomized trial of fenofibrate in type 2 diabetes mellitus suggests that fibrates have beneficial effects and are safe in patients with moderate renal impairment. However, too few participants with chronic kidney disease were included in the study to provide reliable information.

    • David Lewis
    • Christoph Wanner
    News & Views
    Nature Reviews Nephrology
    Volume: 8, P: 201-202

  • 2017 saw the emergence of a new era in renoprotective medicine for diabetic kidney disease with reports of promising renal outcomes with the sodium–glucose cotransporter 2 (SGLT2) inhibitors empagliflozin and canagliflozin from follow-up analyses of the EMPA-REG OUTCOME trial and the CANVAS Program, respectively, and with use of the glucagon-like peptide 1 (GLP1) agonist liraglutide in the LEADER trial.

    • Christoph Wanner
    News & Views
    Nature Reviews Nephrology
    Volume: 14, P: 78-80

  • Inhibitors of sodium–glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP4) are widely used in patients with type 2 diabetes to improve glycaemic control and reduce cardiovascular risks. Two recent clinical trials, CREDENCE and DELIGHT, demonstrate that these drugs can also slow down the progression of kidney disease in these patients.

    • Christoph Wanner
    • Susanne Brenner
    News & Views
    Nature Reviews Nephrology
    Volume: 15, P: 459-460

  • A meta-analysis of individual-level patient data from 66 clinical studies supports the utility of glomerular filtration rate as a surrogate endpoint in clinical trials for chronic kidney disease, with potential to enable detection of events earlier in the disease course.

    • Lesley A. Inker
    • Willem Collier
    • Mauro Saddelli
    Research
    Nature Medicine
    Volume: 29, P: 1867-1876

  • Addressing the burden of non-communicable diseases is a global public health priority. In this joint Consensus Statement, the American Society of Nephrology, the European Renal Association and the International Society of Nephrology highlight the need to recognize kidney disease as a key driver of premature mortality, in addition to other non-communicable diseases already prioritized by the World Health Organization.

    • Anna Francis
    • Meera N. Harhay
    • Vivekanand Jha
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 473-485

  • Here, the authors review techniques for cardiovascular diagnosis, screening and monitoring in patients with CKD, including approaches to the diagnosis of cardiac ischaemia, left ventricular hypertrophy and dysfunction, arrhythmia, cerebrovascular disease, peripheral arterial disease, arterial stiffness and hypertension.

    • Carmine Zoccali
    • Patrick B. Mark
    • Andrzej Wiecek
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 733-746

  • Chronic kidney disease (CKD) is the progressive, irreversible loss of renal function that has many causes and contributing factors. In this Primer, the authors describe the many consequences of CKD and how understanding — and treating — the underlying cause can substantially slow CKD progression.

    • Paola Romagnani
    • Giuseppe Remuzzi
    • Hans-Joachim Anders
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-24