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Showing 1–14 of 14 results
Advanced filters: Author: Christophe Dessimoz Clear advanced filters

  • FastOMA achieves fast and accurate orthology inference, with linear scalability.

    • Sina Majidian
    • Yannis Nevers
    • Christophe Dessimoz
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 269-272

  • Fission yeastSchizosaccharomyces pombe has diverse traits. Jeffares et al. characterize large copy number variations (CNVs) and rearrangements in S. pombe, and show that CNVs are transient with effects on quantitative traits and gene expression, whereas rearrangements influence intrinsic reproductive isolation.

    • Daniel C. Jeffares
    • Clemency Jolly
    • Fritz J. Sedlazeck
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio files) in DNA strands; a ‘DNA archive’ has been synthesized, shipped from the USA to Germany, sequenced and the information read.

    • Nick Goldman
    • Paul Bertone
    • Ewan Birney
    Research
    Nature
    Volume: 494, P: 77-80

  • An analysis of publicly available viral genomes explores the evolutionary dynamics of host jumps and shows that humans are as much a source of viral spillover events to other animals as they are recipients.

    • David Moi
    • Christophe Dessimoz
    News & Views
    Nature Ecology & Evolution
    Volume: 8, P: 854-855

  • Sexual reproduction in eukaryotes involves gamete fusion, mediated by fusogenic proteins. Here, the authors identify fusogenic protein homologs encoded within mobile genetic elements in archaeal genomes, solve the crystal structure of one of the proteins, and show that its ectopic expression can fuse mammalian cells, suggesting potential roles in cell-cell fusion and gene exchange.

    • David Moi
    • Shunsuke Nishio
    • Benjamin Podbilewicz
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

    • Christopher Abbosh
    • Nicolai J. Birkbak
    • Charles Swanton
    Research
    Nature
    Volume: 545, P: 446-451

  • The solution of the longstanding “protein folding problem” in 2021 showcased the transformative capabilities of AI in advancing the biomedical sciences. AI was characterized as successfully learning from protein structure data, which then spurred a more general call for AI-ready datasets to drive forward medical research. Here, we argue that it is the broad availability of knowledge, not just data, that is required to fuel further advances in AI in the scientific ___domain. This represents a quantum leap in a trend toward knowledge democratization that had already been developing in the biomedical sciences: knowledge is no longer primarily applied by specialists in a sub-field of biomedicine, but rather multidisciplinary teams, diverse biomedical research programs, and now machine learning. The development and application of explicit knowledge representations underpinning democratization is becoming a core scientific activity, and more investment in this activity is required if we are to achieve the promise of AI.

    • Christophe Dessimoz
    • Paul D. Thomas
    Comments & OpinionOpen Access
    Scientific Data
    Volume: 11, P: 1-5