Overexpression of certain transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells; however, only a minority of donor somatic cells can be reprogrammed to pluripotency. Here, this reprogramming is shown to be a continuous stochastic process where almost all mouse donor cells eventually give rise to iPS cells on continued growth and transcription factor expression; changing certain parameters results in accelerated iPS cell formation.
- Jacob Hanna
- Krishanu Saha
- Rudolf Jaenisch
