Nature Search

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
The human claustrum tracks slow waves during sleep

The role of the human claustrum during slow wave sleep is unknown. Here the authors characterize the spiking activity of claustrum neurons in humans and demonstrate that claustrum neurons track slow waves during NREM sleep.

Layton Lamsam
Brett Gu
Eyiyemisi C. Damisah
ResearchOpen Access17 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Christopher Pittenger
Ronald S Duman
Reviews12 Sept 2007
Neuropsychopharmacology

Volume: 33, P: 88-109
Author Correction: Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

Farhan Ali
Danielle M. Gerhard
Alex C. Kwan
Amendments and CorrectionsOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Cees J. Weeland
Selina Kasprzak
Chris Vriend
ResearchOpen Access21 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-10
Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

The neurochemical basis of compulsive behaviour is not well understood. Here, the authors show that levels of glutamate and GABA in the supplementary motor area and anterior cingulate cortex relate to compulsive behaviour in healthy controls and individuals with OCD.

Marjan Biria
Paula Banca
Trevor W. Robbins
ResearchOpen Access27 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Information processing style and institutional trust as factors of COVID vaccine hesitancy

Wanchen Zhao
Catherine Maya Russell
Helen Pushkarskaya
ResearchOpen Access06 May 2024
Scientific Reports

Volume: 14, P: 1-17
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.

Farhan Ali
Danielle M. Gerhard
Alex C. Kwan
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology

Roberto Cadeddu
Meghan Van Zandt
Marco Bortolato
Research17 May 2023
Neuropsychopharmacology

Volume: 48, P: 1288-1299
Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Terrence Town
Yasmina Laouar
Richard A Flavell
Research01 Jun 2008
Nature Medicine

Volume: 14, P: 681-687
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions

Cheng Jiang
Ralph J. DiLeone
Ronald S. Duman
ResearchOpen Access12 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-11
Transcriptomic organization of the human brain in post-traumatic stress disorder

A transcriptome-wide characterization of the molecular pathology of post-traumatic stress disorder (PTSD) postmortem brains provides a comprehensive resource for mechanistic insight and therapeutic development.

Matthew J. Girgenti
Jiawei Wang
Ronald S. Duman
Research21 Dec 2020
Nature Neuroscience

Volume: 24, P: 24-33
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth

Rachael G. Grazioplene
Colin G. DeYoung
Christopher Pittenger
ResearchOpen Access10 Aug 2022
Translational Psychiatry

Volume: 12, P: 1-10
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
ResearchOpen Access07 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1063-1074
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
ResearchOpen Access02 May 2023
Molecular Psychiatry

Volume: 28, P: 4307-4319
Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits

Maximiliano Rapanelli
Wei Wang
Zhen Yan
ResearchOpen Access24 Jan 2023
Translational Psychiatry

Volume: 13, P: 1-11
5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice

Sarah J. Jefferson
Ian Gregg
Alex C. Kwan
Research04 Apr 2023
Neuropsychopharmacology

Volume: 48, P: 1257-1266
Early Parental Deprivation in the Marmoset Monkey Produces Long-Term Changes in Hippocampal Expression of Genes Involved in Synaptic Plasticity and Implicated in Mood Disorder

Amanda J Law
Qi Pei
Paul J Harrison
Research09 Jul 2008
Neuropsychopharmacology

Volume: 34, P: 1381-1394
Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

Wei Wang
Dalong Sun
Qing-song Liu
Research21 Jul 2010
Neuropsychopharmacology

Volume: 35, P: 2249-2261
Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation

Farhan Ali
Ling-Xiao Shao
Alex C. Kwan
Research11 Mar 2020
Molecular Psychiatry

Volume: 26, P: 1945-1966
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
Amendments and CorrectionsOpen Access07 Mar 2024
Molecular Psychiatry

Volume: 29, P: 1216
Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Willem B. Bruin
Luke Taylor
Guido A. van Wingen
ResearchOpen Access08 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-12
Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
Amendments and CorrectionsOpen Access15 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4320
Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder

Christie L. Burton
Mathieu Lemire
Paul D. Arnold
ResearchOpen Access02 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-10
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Pritesh Jain
Tyne Miller-Fleming
Peristera Paschou
ResearchOpen Access23 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders

M Rapanelli
L Frick
C Pittenger
ResearchOpen Access24 Jan 2017
Translational Psychiatry

Volume: 7, P: e1013
White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

Fabrizio Piras
Federica Piras
Gianfranco Spalletta
ResearchOpen Access17 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11

Search

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

The human claustrum tracks slow waves during sleep

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Author Correction: Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

Information processing style and institutional trust as factors of COVID vaccine hesitancy

Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions

Transcriptomic organization of the human brain in post-traumatic stress disorder

Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth

White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits

5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice

Early Parental Deprivation in the Marmoset Monkey Produces Long-Term Changes in Hippocampal Expression of Genes Involved in Synaptic Plasticity and Implicated in Mood Disorder

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation

Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders

White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

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