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Showing 1–11 of 11 results
Advanced filters: Author: Christos Spanos Clear advanced filters

  • Loss of an snoRNA causes the neurodevelopmental disease Prader-Willi Syndrome (PWS). Here the authors generate snoRNA-deleted pre-neuronal cell lines. Small numbers of RNAs and proteins were altered, with functions potentially linked to PWS symptoms.

    • Aleksandra Helwak
    • Tomasz Turowski
    • David Tollervey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The African trypanosome Trypanosoma brucei has been shown to form stress granules in vitro that might be repurposed to enable differentiation and facilitate parasite transmission. Here, Cayla et al. show that differentiation between slender and stumpy forms does involve membrane-less granules that are different from nutritional stress granules.

    • Mathieu Cayla
    • Christos Spanos
    • Keith R. Matthews
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • During nuclear surveillance in yeast and human cells, the RNA exosome functions together with the TRAMP complexes. Here, the authors defined the protein composition of the TRAMP complexes and identified specific RNA binding sites for the different TRAMP components.

    • Clémentine Delan-Forino
    • Christos Spanos
    • David Tollervey
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • A 3.9-Ã…-resolution cryo-EM structure of the S. cerevisiae OCCM replicative helicase loading complex bound to DNA shows how ORC and Cdc6 recognize DNA origins, and reveals details of how the Mcm2–7 hexamer ring is loaded onto the DNA helix.

    • Zuanning Yuan
    • Alberto Riera
    • Huilin Li
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 316-324

  • Here, the authors find that histone demethylase Epe1-mediated stress resistance is regulated by proteasome-dependent truncation, allowing heterochromatin to reprogram gene expression that confers antifungal resistance to some fission yeast cells in the population.

    • Imtiyaz Yaseen
    • Sharon A. White
    • Robin C. Allshire
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 745-758

  • Mutations in the non-coding RNA RMRP cause primary immunodeficiency. Robertson et al show that a disease-associated mutation in RMRP impairs pre-ribosomal RNA processing and reduces ribosome abundance, establishing this disorder as a ribosomopathy.

    • Nic Robertson
    • Vadim Shchepachev
    • David Tollervey
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Lamin A is critical for nuclear architecture but its structure and assembly are not fully understood. Here, the authors use quantitative cross-linking mass spectrometry to map intra- and intermolecular interactions within lamin homomers, providing insights into the molecular basis for lamin’s mechanical properties.

    • Alex A. Makarov
    • Juan Zou
    • Eric C. Schirmer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.

    • Inês J. de Castro
    • James Budzak
    • Paola Vagnarelli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16