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Showing 1–4 of 4 results
Advanced filters: Author: Chuanxun Fu Clear advanced filters
  • This study reports the design of heterogated nanoprobes for interval-based pH imaging in biological systems, including cellular endocytic organelles and tumours. The modular design allows for fine-tuning of pH transition point and fluorescent emission.

    • Ye Yang
    • Binlong Chen
    • Yiguang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Optical nanoprobes with preferential tumour accumulation is often limited by inefficient amplification of biological signals. Here, the authors report a hydrophobic core-tunable nanoprobe orthogonally amplifying tumour microenvironmental signals and demonstrating clear delineation between malignant lesions and normal tissues on multiple tumour models.

    • Meijie Pan
    • Ruiyang Zhao
    • Yiguang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • A high abundance of tumour associated macrophages with immunosuppressive properties is associated with inefficient anti-tumour immune responses. Here the authors report the design and characterization of pH-gated nanoparticles selectively targeting and reprogramming M2-like macrophages in the tumour microenvironment, re-sensitizing tumours to immune checkpoint blockade.

    • Mingmei Tang
    • Binlong Chen
    • Yiguang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16