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Showing 1–9 of 9 results

Advanced filters: Author: Chun-Cheih Chao Clear advanced filters

Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong-Gyun Lee
Joseph M. Rone
Francisco J. Quintana
Amendments and Corrections21 Jun 2024
Nature

Volume: 631, P: E8
Identification of environmental factors that promote intestinal inflammation

The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflammation—is targeted by propyzamide.

Liliana M. Sanmarco
Chun-Cheih Chao
Francisco J. Quintana
Research20 Oct 2022
Nature

Volume: 611, P: 801-809
Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C. Takenaka
Galina Gabriely
Francisco J. Quintana
Amendments and Corrections13 Jun 2019
Nature Neuroscience

Volume: 22, P: 1533
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model

The mechanisms of pathological astrocyte responses during multiple sclerosis remain unclear. Kadowaki et al. found in MS mouse models that CLEC16A suppresses astrocyte pathogenic activities related to mitochondria by boosting mitophagy.

Atsushi Kadowaki
Michael A. Wheeler
Francisco J. Quintana
Research03 Mar 2025
Nature Neuroscience

Volume: 28, P: 470-486
Disease-associated astrocyte epigenetic memory promotes CNS pathology

In an experimental autoimmune encephalomyelitis model in mice, a subset of astrocytes retains an epigenetically regulated memory of past inflammation, causing exacerbated inflammation upon subsequent rechallenge.

Hong-Gyun Lee
Joseph M. Rone
Francisco J. Quintana
Research20 Mar 2024
Nature

Volume: 627, P: 865-872
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

Lactate produced by dendritic cells (DCs) suppresses T-cell-mediated autoimmunity through a mechanism in which lactate activates HIF-1α–NDUFA4L2 signalling in DCs and thereby limits DC-mediated pro-inflammatory responses such as the development of encephalitogenic T cells.

Liliana M. Sanmarco
Joseph M. Rone
Francisco J. Quintana
Research09 Aug 2023
Nature

Volume: 620, P: 881-889
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Using animal models and clinical samples, the authors report that glioblastoma metabolites activate the transcription factor aryl hydrocarbon receptor in tumor-associated macrophages to modulate their function and T cell immunity, promoting tumor growth.

Maisa C. Takenaka
Galina Gabriely
Francisco J. Quintana
Research08 Apr 2019
Nature Neuroscience

Volume: 22, P: 729-740
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

After upregulation of AHR in astrocytes by type I interferons, commensal-microbe-derived metabolites of dietary tryptophan act on astrocytes to suppress CNS inflammation.

Veit Rothhammer
Ivan D Mascanfroni
Francisco J Quintana
Research09 May 2016
Nature Medicine

Volume: 22, P: 586-597
Microglial control of astrocytes in response to microbial metabolites

TGFα and VEGF-B produced by microglia regulate astrocyte function in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

Veit Rothhammer
Davis M. Borucki
Francisco J. Quintana
Research16 May 2018
Nature

Volume: 557, P: 724-728