Nature Search

Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces cerevisiae

Here, the authors show that a modular deregulation strategy in Saccharomyces cerevisiae boosts xylose conversion to 3-HP by engineering central carbon metabolism with five strategies, achieving a 4.7-fold productivity increase over an initially optimized strain using xylose.

Xiaowei Li
Yanyan Wang
Yun Chen
ResearchOpen Access16 May 2025
Nature Communications

Volume: 16, P: 1-16
A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Medium- and branched-chain diols and amino alcohols are important industrial feedstocks, but they are biosynthetically challenging to produce. Here the authors introduce a modular polyketide synthase platform for the efficient production of these compounds.

Qingyun Dan
Yan Chiu
Jay D. Keasling
ResearchOpen Access11 Feb 2025
Nature Catalysis

Volume: 8, P: 147-161
Complete biosynthesis of QS-21 in engineered yeast

QS-21—an FDA-approved vaccine adjuvant—and several structural analogues of QS-21 can be synthesized in engineered yeast strains, and this process is much less laborious compared with the conventional mode of extraction from the Chilean soapbark tree.

Yuzhong Liu
Xixi Zhao
Jay D. Keasling
ResearchOpen Access08 May 2024
Nature

Volume: 629, P: 937-944
Multivalent Cu sites synergistically adjust carbonaceous intermediates adsorption for electrocatalytic ethanol production

This study proposes a multivalent Cu-based catalyst (Cu-TAPT) for electrocatalytic CO₂RR, which promotes specific intermediate formation by the synergy of Cu²⁺ and Cu⁺ sites, thereby achieving a 54.3% Faradaic efficiency of ethanol at 429 mA cm⁻².

Xiao Chen
Shuaiqiang Jia
Buxing Han
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-9
Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

Saccharomyces cerevisiae can be engineered to slowly use methanol; however, a co-carbon source is usually required to support its growth. Now, a Saccharomyces cerevisiae strain that can use methanol as the sole carbon source for growth, and produce value-added bioproducts, is developed.

Chunjun Zhan
Xiaowei Li
Zhonghu Bai
Research15 May 2023
Nature Catalysis

Volume: 6, P: 435-450
A hydrophobic Cu/Cu₂O sheet catalyst for selective electroreduction of CO to ethanol

Tuning electrocatalytic reduction of carbon monoxide to achieve valuable ethanol product with high performance is interesting yet challenging. Here, the authors design a hydrophobic Cu/Cu₂O sheet catalyst showing a FE of 68.8% and partial current density of 111 mA cm⁻² for CO reduction to ethanol.

Guifeng Ma
Olga A. Syzgantseva
Buxing Han
ResearchOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1-9
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Fusheng Zhou
Hongzhi Cao
Xuejun Zhang
Research23 May 2016
Nature Genetics

Volume: 48, P: 740-746
Oxidation of metallic Cu by supercritical CO₂ and control synthesis of amorphous nano-metal catalysts for CO₂ electroreduction

Amorphous metal catalysts often exhibit appealing catalytic properties, however, accurate control synthesis of amorphous nano-metal catalysts is a challenge. Here, the authors report a feasible strategy to prepare the amorphous Cu catalysts by supercritical CO₂ treatment followed by electroreduction. The resulted catalyst shows high selectivity towards multi-carbon products for CO₂ electroreduction.

Chunjun Chen
Xupeng Yan
Buxing Han
ResearchOpen Access25 Feb 2023
Nature Communications

Volume: 14, P: 1-10
In situ dual doping for constructing efficient CO₂-to-methanol electrocatalysts

Production of methanol from CO₂ electroreduction is attractive but achieving high selectivity, current density and stability simultaneously remains a grand challenge. Here, the authors present an in situ dual doping strategy to construct efficient CO₂-to-methanol electrocatalysts.

Pengsong Li
Jiahui Bi
Buxing Han
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-9
Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Bingwei Ma
Yao Chen
Shen Qu
Research31 Mar 2021
European Journal of Clinical Nutrition

Volume: 75, P: 1645-1653
Selective electroreduction of carbon dioxide to methanol on copper selenide nanocatalysts

While the conversion of CO₂ to valuable, storable chemicals is attractive, there are few inexpensive and abundant catalysts that are also active and selective for liquid fuels. Here, the authors study copper selenide as a high-performing and efficient electrocatalyst for CO₂ conversion to methanol.

Dexin Yang
Qinggong Zhu
Buxing Han
ResearchOpen Access08 Feb 2019
Nature Communications

Volume: 10, P: 1-9
TanCAR T cells targeting CD19 and CD133 efficiently eliminate MLL leukemic cells

Dan Li
Yutian Hu
Han Liu
Research25 Jul 2018
Leukemia

Volume: 32, P: 2012-2016
Correction to: Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Bingwei Ma
Yao Chen
Shen Qu
Amendments and Corrections12 May 2022
European Journal of Clinical Nutrition

Volume: 76, P: 1630
Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia

Shouhai Zhu
Xiaoyan Cheng
Han Liu
ResearchOpen Access24 Feb 2020
Leukemia

Volume: 34, P: 2484-2488
MLL is required for miRNA-mediated translational repression

Shouhai Zhu
Zhihong Chen
Han Liu
CorrespondenceOpen Access03 Sept 2019
Cell Discovery

Volume: 5, P: 1-5

Search

Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces cerevisiae

A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Complete biosynthesis of QS-21 in engineered yeast

Multivalent Cu sites synergistically adjust carbonaceous intermediates adsorption for electrocatalytic ethanol production

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

A hydrophobic Cu/Cu₂O sheet catalyst for selective electroreduction of CO to ethanol

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Oxidation of metallic Cu by supercritical CO₂ and control synthesis of amorphous nano-metal catalysts for CO₂ electroreduction

In situ dual doping for constructing efficient CO₂-to-methanol electrocatalysts

Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Selective electroreduction of carbon dioxide to methanol on copper selenide nanocatalysts

TanCAR T cells targeting CD19 and CD133 efficiently eliminate MLL leukemic cells

Correction to: Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia

MLL is required for miRNA-mediated translational repression

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