Nature Search

Electronic vascular conduit for in situ identification of hemadostenosis and thrombosis in small animals and nonhuman primates

Arterial vascular grafts are promising for vascular reconstruction but face risk of restenosis. Here, the authors report an electronic vascular conduit for in situ, long-term monitoring of thrombosis concurrent with postoperative vascular repair in in small animals and nonhuman primates.

Zhirong Liu
Chuyu Tang
Linlin Li
ResearchOpen Access18 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Graphene/silicon heterojunction for reconfigurable phase-relevant activation function in coherent optical neural networks

Designing an efficient activation function for optical neural networks remains a challenge. Here, the authors demonstrate a modulator-detector-in-one graphene/silicon heterojunction ring resonators enabling on-chip reconfigurable activation function devices with phase activation capability for optical neural networks.

Chuyu Zhong
Kun Liao
Hongtao Lin
ResearchOpen Access31 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2α.

Jialin Xia
Hong Chen
Yanli Pang
ResearchOpen Access04 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Qi Qu
Yan Chen
Sheng-Cai Lin
Amendments and CorrectionsOpen Access28 Jan 2025
Nature

Volume: 638, P: E6
Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Xinyu Qi
Chuyu Yun
Jie Qiao
Amendments and Corrections30 Aug 2019
Nature Medicine

Volume: 25, P: 1459
Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.

Qi Qu
Yan Chen
Sheng-Cai Lin
ResearchOpen Access18 Dec 2024
Nature

Volume: 643, P: 192-200
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating GLP-1 levels through suppression of hepatic CYP8B1 expression and bile acid mediated inhibition of intestinal FXR signalling.

Ying Yan
Zhoumin Niu
Hao Ying
ResearchOpen Access27 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Modifying the gut microbiota, bile acid, or IL-22 may offer an alternative approach for the treatment of polycystic ovary syndrome.

Xinyu Qi
Chuyu Yun
Jie Qiao
Research22 Jul 2019
Nature Medicine

Volume: 25, P: 1225-1233

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