Nature Search

VDAC2 loss elicits tumour destruction and inflammation for cancer therapy

VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

Sujing Yuan
Renqiang Sun
Hongbo Chi
ResearchOpen Access19 Mar 2025
Nature

Volume: 640, P: 1062-1071
Retraction Note: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Jennifer Martinez
Larissa D. Cunha
Douglas R. Green
Amendments and Corrections31 Aug 2022
Nature

Volume: 609, P: 640
Correction: Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Jennifer Martinez
Larissa D. Cunha
Douglas R. Green
Amendments and Corrections28 Sept 2016
Nature

Volume: 539, P: 124
Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

Xin Lan
Tian Mi
Ben Youngblood
Research30 May 2024
Nature Immunology

Volume: 25, P: 1046-1058
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Competition for glutamine between type-1 conventional dendritic cells and tumour cells has a central role in tuning the anti-tumour immune response and in immune evasion by cancer cells.

Chuansheng Guo
Zhiyuan You
Hongbo Chi
ResearchOpen Access05 Jul 2023
Nature

Volume: 620, P: 200-208
CXCR6 orchestrates brain CD8⁺ T cell residency and limits mouse Alzheimer’s disease pathology

Chi and colleagues identify brain-resident CXCR6⁺PD-1⁺CD8⁺ T cells that interact with resident microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s disease.

Wei Su
Jordy Saravia
Hongbo Chi
Research07 Sept 2023
Nature Immunology

Volume: 24, P: 1735-1747
Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions

It is unclear how incoming influenza viruses counteract the cells’ first line of defence, the interferon (IFN) response. Here Liedmann et al.show that a distinct amino-acid motif in polymerases PB1 and PA, which are packaged in the viral particles, inhibit early IFN induction.

Swantje Liedmann
Eike R. Hrincius
Christina Ehrhardt
ResearchOpen Access09 Dec 2014
Nature Communications

Volume: 5, P: 1-8
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

CRISPR screening and protein–protein interaction networks identify components and mechanisms of nutrient-dependent mTORC1 signalling in regulatory T cells and reveal how mTORC1 integrates immunological cues and nutrient signals for adaptive immunity.

Lingyun Long
Jun Wei
Hongbo Chi
Research18 Nov 2021
Nature

Volume: 600, P: 308-313
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8⁺ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.

Jun Wei
Lingyun Long
Hongbo Chi
Research11 Dec 2019
Nature

Volume: 576, P: 471-476
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

Acne vulgarisis a common, inflammatory skin disorder. Here the authors carry out a genome-wide association study and identify three genetic variants that associate with an increased risk of developing acne, which together suggest a mechanistic role for the TGFβ cell signalling pathway in acne development and progression.

Alexander A. Navarini
Michael A. Simpson
Jonathan N. Barker
Research13 Jun 2014
Nature Communications

Volume: 5, P: 1-6
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.

Mei Yu
Yuhong Chen
Demin Wang
ResearchOpen Access13 Nov 2017
Nature Communications

Volume: 8, P: 1-18
T_reg cells require the phosphatase PTEN to restrain T_H1 and T_FH cell responses

T_reg cells control effector cells such as T_H1 and T_FH cells. Chi and colleagues demonstrate that PTEN is cell-intrinsically required for T_reg cell lineage stability and regulation of effector T cell responses.

Sharad Shrestha
Kai Yang
Hongbo Chi
Research05 Jan 2015
Nature Immunology

Volume: 16, P: 178-187
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Regulatory T (T_reg) cells have a distinct cellular metabolism compared to effector T cells. Chi and colleagues show that autophagy is required to maintain the functional integrity and metabolic homeostasis of T_reg cells in the face of inflammatory environmental cues.

Jun Wei
Lingyun Long
Hongbo Chi
Research25 Jan 2016
Nature Immunology

Volume: 17, P: 277-285
IL-35-mediated induction of a potent regulatory T cell population

IL-35 is an immunomodulatory cytokine secreted by regulatory T cells. Vignali and colleagues demonstrate that IL-35 also mediates the induction of a unique regulatory population that may underpin infectious tolerance.

Lauren W Collison
Vandana Chaturvedi
Dario A A Vignali
Research17 Oct 2010
Nature Immunology

Volume: 11, P: 1093-1101
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.

Christos Petridis
Alexander A. Navarini
Michael A. Simpson
ResearchOpen Access12 Dec 2018
Nature Communications

Volume: 9, P: 1-8
Distinct developmental outcomes in DNA repair-deficient FANCC c.67delG mutant and FANCC^−/− Mice

Swarna Beesetti
Cliff Guy
Douglas R. Green
Research17 Feb 2025
Cell Death & Differentiation

P: 1-9
A self-healing ferroelectric liquid crystal electro-optic shutter based on vertical surface-relief grating alignment

Ferroelectric liquid crystals (FLCs) have faster optical response times than nematic crystals, but they are also less robust to external shock. Here the authors develop an FLC geometry that reduces the sensitivity to external disruption through self-healing, making them more stable for applications.

Peter J. M. Wyatt
James Bailey
J. Cliff Jones
ResearchOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Hippo/Mst signalling couples metabolic state and immune function of CD8α⁺ dendritic cells

A data-driven analysis helps to identify specific roles of the Hippo signalling kinases Mst1 and Mst2 in integrating metabolic activity and cytokine signalling in dendritic cells, and thereby orchestrating immune cell function.

Xingrong Du
Jing Wen
Hongbo Chi
Research30 May 2018
Nature

Volume: 558, P: 141-145
RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Defects in LC3-associated phagocytosis in mice are shown to result in systemic lupus erythematosus-like disease; dying cells are engulfed but not degraded in LAP-deficient mice, resulting in increased serum levels of autoantibodies and inflammatory cytokines, and evidence of kidney disease.

Jennifer Martinez
Larissa D. Cunha
Douglas R. Green
Research20 Apr 2016
Nature

Volume: 533, P: 115-119
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Neuropilin-1 (Nrp1) on regulatory T (T_reg) cells is shown to interact with semaphorin-4a (Sema4a) to promote a program of T_reg-cell stability and survival, in part through PTEN-mediated modulation of Akt signalling; Nrp1-deficient T_reg cells can maintain immune homeostasis but fail to suppress in inflammatory sites, such as tumours, providing an attractive immunotherapeutic target for the treatment of cancers.

Greg M. Delgoffe
Seng-Ryong Woo
Dario A. A. Vignali
Research04 Aug 2013
Nature

Volume: 501, P: 252-256
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

The asymmetric distribution of mTORC1 and c-Myc in the first division of daughter cells of activated CD8 T cells affects the proliferation, metabolism and differentiation potential of their progeny.

Katherine C. Verbist
Cliff S. Guy
Douglas R. Green
Research11 Apr 2016
Nature

Volume: 532, P: 389-393
Unified metagenomic method for rapid detection of microorganisms in clinical samples

Alcolea-Medina et al. develop a rapid, unified metagenomics method for the detection of bacteria, fungi, and viruses from clinical respiratory samples. This method reduces human DNA content, allowing efficient pathogen detection and possibility of same-day reporting to meet requirements of clinical implementation.

Adela Alcolea-Medina
Christopher Alder
Jonathan D. Edgeworth
ResearchOpen Access07 Jul 2024
Communications Medicine

Volume: 4, P: 1-13
Ca²⁺-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak

Giovanni Quarato
Fabien Llambi
Douglas R. Green
Research20 Jun 2022
Cell Death & Differentiation

Volume: 29, P: 1318-1334
LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Yanyan Wang
Xingrong Du
Hongbo Chi
Research25 Mar 2019
Cell Research

Volume: 29, P: 391-405
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

Search

VDAC2 loss elicits tumour destruction and inflammation for cancer therapy

Retraction Note: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Correction: Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

CXCR6 orchestrates brain CD8⁺ T cell residency and limits mouse Alzheimer’s disease pathology

Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

T_reg cells require the phosphatase PTEN to restrain T_H1 and T_FH cell responses

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

IL-35-mediated induction of a potent regulatory T cell population

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Distinct developmental outcomes in DNA repair-deficient FANCC c.67delG mutant and FANCC^−/− Mice

A self-healing ferroelectric liquid crystal electro-optic shutter based on vertical surface-relief grating alignment

Hippo/Mst signalling couples metabolic state and immune function of CD8α⁺ dendritic cells

RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Unified metagenomic method for rapid detection of microorganisms in clinical samples

Ca²⁺-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

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