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Drug repositioning for Alzheimer's disease

Preclinical research indicates that various drugs approved for indications such as hypertension and diabetes could also have potentially beneficial effects in Alzheimer's disease, and for some drugs the evidence is also supported by epidemiological data or preliminary clinical trials. This article presents a formal consensus evaluation of these drug repositioning opportunities, and highlights several compounds for which sufficient evidence is available to encourage further investigation and potential progression to clinical trials in Alzheimer's disease.

Anne Corbett
James Pickett
Clive Ballard
Reviews05 Nov 2012
Nature Reviews Drug Discovery

Volume: 11, P: 833-846
Climate of mistrust

Clive Bates
Correspondence23 Jan 1997
Nature

Volume: 385, P: 290
Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development

Gordon Peters
Audrey E. Lee
Clive Dickson
Research17 May 1984
Nature

Volume: 309, P: 273-275
Cytoplasmic microtubules of higher plant cells visualised with anti-tubulin antibodies

CLIVE W. LLOYD
ANTONI R. SLABAS
R. A. BADLEY
Research17 May 1979
Nature

Volume: 279, P: 239-241
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

Oxana Ibraghimov-Beskrovnaya
James M. Ervasti
Kevin P. Campbell
Research20 Feb 1992
Nature

Volume: 355, P: 696-702
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Liquid sulphur lakes at Poás volcano

Clive Oppenheimer
David Stevenson
Research14 Dec 1989
Nature

Volume: 342, P: 790-793
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
Characterization of murine Flt4 ligand/VEGF-C

Lori J Fitz
John C Morris
Clive R Wood
Research31 Jul 1997
Oncogene

Volume: 15, P: 613-618
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Past genome-wide associate studies have identified hundreds of genetic loci that influence body size and shape when examined one trait at a time. Here, Jeff and colleagues develop an aggregate score of various body traits, and use meta-analysis to find new loci linked to body shape.

Janina S. Ried
Janina Jeff M.
Ruth J. F. Loos
ResearchOpen Access23 Nov 2016
Nature Communications

Volume: 7, P: 1-11
Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids

Andrea R. Marti
Torhild T. Pedersen
Janne Grønli
ResearchOpen Access04 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

Yingchang Lu
Felix R. Day
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.

Tuomas O. Kilpeläinen
Jayne F. Martin Carli
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-14
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Denise Harold
Richard Abraham
Julie Williams
Amendments and Corrections01 Oct 2009
Nature Genetics

Volume: 41, P: 1156
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy

Sanjay Popat
Adam Januszewski
William Wilson
ResearchOpen Access05 Dec 2024
British Journal of Cancer

Volume: 132, P: 245-252
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Mild iodine deficiency is associated with elevated hearing thresholds in children in Benin

T van den Briel
CE West
EA Ategbo
Research30 Aug 2001
European Journal of Clinical Nutrition

Volume: 55, P: 763-768
Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Denise Harold
Richard Abraham
Julie Williams
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 712
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

An exciting genome-wide association study in the British population for seven common diseases. This analysis confirms previously identified loci and provides strong evidence for many novel disease susceptibility loci.

Paul R. Burton
David G. Clayton
Jane Worthington
Research07 Jun 2007
Nature

Volume: 447, P: 661-678
Multi-ethnic genome-wide association study for atrial fibrillation

This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

Carolina Roselli
Mark D. Chaffin
Patrick T. Ellinor
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 1225-1233
Can resistant infections be perceptible in UK dairy farming?

Richard Helliwell
Carol Morris
Sujatha Raman
ResearchOpen Access05 Feb 2019
Palgrave Communications

Volume: 5, P: 1-9
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

New methods and larger sample groups are used to precisely determine the alleles in the HLA complex which contribute susceptibility to type 1 diabetes.

Sergey Nejentsev
Joanna M. M. Howson
Jane Worthington
Research14 Nov 2007
Nature

Volume: 450, P: 887-892
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 and MS4A6A/MS4A4E associated with Alzheimer's disease and support for several additional susceptibility loci.

Paul Hollingworth
Denise Harold
Julie Williams
Research03 Apr 2011
Nature Genetics

Volume: 43, P: 429-435
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Julie Williams and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants at the CLU and PICALM loci associated with susceptibility to late-onset Alzheimer's disease.

Denise Harold
Richard Abraham
Julie Williams
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1088-1093
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

Whole-exome sequencing reveals that a rare variant of phospholipase D3 (PLD3(V232M)) segregates with Alzheimer’s disease status in two independent families and doubles risk for the disease in case–control series, and that several other PLD3 variants increase risk for Alzheimer’s disease in African Americans and people of European descent.

Carlos Cruchaga
Celeste M. Karch
Alison M. Goate
Research11 Dec 2013
Nature

Volume: 505, P: 550-554
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease

Byron Creese
Evangelos Vassos
Geir Selbaek
ResearchOpen Access22 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-10
Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males

Clive M. Gray
Kyle L. O’Hagan
Thomas J. Hope
ResearchOpen Access16 Oct 2019
Mucosal Immunology

Volume: 13, P: 118-127
Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence

C D Morris
A Rose
D J Webb
ResearchOpen Access14 Jun 2005
British Journal of Cancer

Volume: 92, P: 2148-2152
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study

Jonathan E. Millar
Lucile Neyton
Peter Young
ResearchOpen Access27 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction

J D Lickliter
J Cox
A J Nicol
ResearchOpen Access20 Feb 2007
British Journal of Cancer

Volume: 96, P: 600-608

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