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Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome

In participants from a randomized controlled trial, doxy-PEP use over 6 months minimally affected the gut microbiome’s taxonomic composition but increased the abundance and active expression of tetracycline antibiotic resistance genes.

Victoria T. Chu
Abigail Glascock
Charles R. Langelier
ResearchOpen Access03 Oct 2024
Nature Medicine

Volume: 31, P: 207-217
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results

In a prespecified 3-year analysis of the KEN SHE trial, single-dose HPV vaccination was shown to be well tolerated and provided durable protection against cervical HPV infection in Kenyan women aged 15–20 years.

Ruanne V. Barnabas
Elizabeth R. Brown
Torin T. Schaafsma
ResearchOpen Access04 Dec 2023
Nature Medicine

Volume: 29, P: 3224-3232
Validation of clinic-based cryptococcal antigen lateral flow assay screening in HIV-infected adults in South Africa

Paul K. Drain
Ting Hong
Connie Celum
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Efficacy estimates of oral pre-exposure prophylaxis for HIV prevention in cisgender women with partial adherence

Pre-exposure prophylaxis (PrEP) with daily antiretrovirals to prevent human immunodeficiency virus type 1 acquisition has not been shown to be consistently effective in cisgender women. Modeling adherence to daily PrEP clarifies how robust protection can be achieved.

Mia Moore
Sarah Stansfield
Dobromir Dimitrov
Research05 Oct 2023
Nature Medicine

Volume: 29, P: 2748-2752
Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya

Smritee Dabee
Nelly Mugo
Deborah Donnell
ResearchOpen Access14 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Worldwide circulation of HSV-2 × HSV-1 recombinant strains

David M. Koelle
Peter Norberg
Christine Johnston
ResearchOpen Access13 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Implementation of a fully remote randomized clinical trial with cardiac monitoring

Mayfield et al. describe the implementation and feasibility of an exclusively remote randomized clinical trial of hydroxychloroquine and azithromycin for the treatment of COVID-19. The trial included monitoring of cardiovascular safety which was successfully done using digital technologies.

Jacob J. Mayfield
Neal A. Chatterjee
Arun R. Sridhar
ResearchOpen Access20 Dec 2021
Communications Medicine

Volume: 1, P: 1-10

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Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome

Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results

Validation of clinic-based cryptococcal antigen lateral flow assay screening in HIV-infected adults in South Africa

Efficacy estimates of oral pre-exposure prophylaxis for HIV prevention in cisgender women with partial adherence

Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya

Worldwide circulation of HSV-2 × HSV-1 recombinant strains

Implementation of a fully remote randomized clinical trial with cardiac monitoring

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