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Clonal haematopoiesis and risk of chronic liver disease

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Research12 Apr 2023
Nature

Volume: 616, P: 747-754
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.

Connor A. Emdin
Amit V. Khera
Sekar Kathiresan
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-8
Author Correction: Clonal haematopoiesis and risk of chronic liver disease

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Amendments and Corrections03 Jul 2023
Nature

Volume: 619, P: E47
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

Erik L. Bao
Satish K. Nandakumar
Vijay G. Sankaran
Research14 Oct 2020
Nature

Volume: 586, P: 769-775
Exome-wide association study of plasma lipids in >300,000 individuals

Exome-wide genetic analysis on >300,000 individuals identifies associations with plasma lipid traits. Loci significantly associated with cholesterol and triglycerides are examined together to determine the effects of alleles on type 2 diabetes and coronary artery disease risk.

Dajiang J Liu
Gina M Peloso
Sekar Kathiresan
Research30 Oct 2017
Nature Genetics

Volume: 49, P: 1758-1766
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

Analysis of genetic data and blood lipid measurements from over 300,000 participants in the Million Veteran Program identifies new associations for blood lipid traits.

Derek Klarin
Scott M. Damrauer
Themistocles L. Assimes
Research01 Oct 2018
Nature Genetics

Volume: 50, P: 1514-1523
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4^−/− mice on a high-fat diet show improved insulin sensitivity.

Viktoria Gusarova
Colm O’Dushlaine
Jesper Gromada
ResearchOpen Access13 Jun 2018
Nature Communications

Volume: 9, P: 1-11
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

Sekar Kathiresan and colleagues perform a genome-wide association test for coronary artery disease (CAD) using data from the UK Biobank. They identify 15 new loci and perform phenome-wide association scanning, implicating insulin resistance pathways and transendothelial migration of leukocytes in CAD.

Derek Klarin
Qiuyu Martin Zhu
Sekar Kathiresan
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1392-1397

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Clonal haematopoiesis and risk of chronic liver disease

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Author Correction: Clonal haematopoiesis and risk of chronic liver disease

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Exome-wide association study of plasma lipids in >300,000 individuals

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

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