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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial

Cabozantinib, an inhibitor of multiple receptor tyrosine kinases, has efficacy in a mouse model of neurofibromatosis type I and has clinical activity in reducing plexiform neurofibroma volume in a phase II trial of patients with NF1.

Michael J. Fisher
Chie-Schin Shih
D. Wade Clapp
Research13 Jan 2021
Nature Medicine

Volume: 27, P: 165-173

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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial

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