Edmunds et al. examine how the adenosine receptor A2AR and the checkpoint molecule TIM3 suppress the killing of Renca tumors expressing hemagglutinin (HA) as a model neo-antigen by CL4 TCR transgenic T cells, which recognize an HA peptide presented by H-2Kd. The authors report that TIM3, which is upregulated on tumor-infiltrating CD8+ T cells after inhibition of A2AR, and A2AR impair the cytoskeletal polarization of the CL4 T cells.
- Grace L. Edmunds
- Carissa C. W. Wong
- David J. Morgan
