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RNA fragments derived from cleaved transfer RNAs play roles in gene regulation and cell proliferation. Here, the authors report that upon ER stress, an ER ribonuclease produces a specific tRNA fragment that promotes cancer cell proliferation and modulates mRNA alternative splicing.

Nanostructured superconductors allow dissipationless electrical transport to be exploited in technologically relevant devices. Here, the authors follow how detrimental fluctuations of the superconducting order parameter evolve in Al atomic contacts as their width is controlled by electromigration.

The charge-density-wave state in RbV₃Sb₅ can be optically manipulated by applying linearly polarized light along high-symmetry directions, which demonstrates the potential of light as a control knob to manipulate complex quantum phenomena in correlated materials.

The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and dynamics that are verified with calcium imaging data.

Lattice anchoring, in its varied forms, has proven effective at regulating the energetics of metastable phases of polymorphic crystals. Here, the authors utilize top-down photolithography to embed a tessellating 3D interfacial network into otherwise-unstable CsPbI₃ perovskite thin films and devices, stabilizing the perovskite phase.

Stable sub-cycle pulses in the mid-infrared region allow damage-free investigation of electron dynamics in solids. Here, the authors develop a suitable source to this end which is based on an optical parametric amplifier.

Overall, this study describes the molecular mechanism of a druggable pathway that recapitulates in cellular assays the immunomodulatory effects associated with Akkermansia muciniphila, a prominent member of the gut microbiota.

Secondary and selected exploratory endpoints of the DESTINY-Breast03 trial of trastuzumab deruxtecan or trastuzumab emtansine in patients with advanced HER2-positive breast cancer are reported, including updated efficacy and safety data after a median follow-up of 41 months.

The mechanisms behind CO₂ dependency in non-autotrophic bacterial isolates are unclear. Here the authors show that the Staphylococcus aureus mpsAB operon is crucial for growth at atmospheric CO₂ levels, and provide evidence indicating that MpsAB represents a bicarbonate concentrating system.

The inherent porosity of auxetic metamaterials challenge their applicability. Here, the authors introduce a seamless auxetic substrate film capable of achieving a negative Poisson’s ratio of −1 incorporating a rigid auxetic structure reinforced by glass-fabric, with surface-flattening soft elastomers applied as an image distortion-free display.

Using high-resolution orbital imagery of the Martian surface, the authors Salese et al. here describe the first discovered stratigraphic product of multiple extensive fluvial-channel belts in an exposed vertical section at Izola Mensa in the northwestern rim of the Hellas Basin.

This Brain Somatic Mosaicism Network analysis of 283 cases of malformations of cortical development identifies 69 candidate and known genes in 76 patients. Single-nucleus RNA sequencing and mouse modeling implicate radial glia and daughter excitatory neurons.

Rana et al. report octupole moment-driven local energetic offsets in Cl₆-SubPc, which leads to direct free charge generation when serves as the electron acceptor layer in planar heterojunction organic photodetectors, exhibiting significant potential for single- and multi-layer optoelectronic devices.

Metal-organic frameworks are promising candidates for capturing and sequestering carbon dioxide. Chen and co-workers report a metal-organic framework that exhibits high uptake of carbon dioxide at ambient conditions, and is a potentially useful adsorbent for post-combustion carbon dioxide capture.

Monolithic 3D integration of electronics based on fully 2D materials is demonstrated in the performance of artificial intelligence tasks.

Structural deformation can modify the optical properties of quantum dots. Here, the author report strain-graded CdSe-ZnSe quantum dots, allowing for spectrally stable and pure emission of photons at accelerated rates with near unity luminescence efficiency.

Few synthetic CO₂-fixation pathways have been tested in vivo. Now, the new-to-nature THETA cycle is designed, realized in vitro and modular implemented in vivo. This cycle involves 17 enzymes, including the two most active carboxylases known so far, to produce the central building block acetyl-CoA using CO₂.

We create a computational model of the adult Drosophila brain that accurately describes circuit responses upon activation of different gustatory and mechanosensory subtypes and generates experimentally testable hypotheses to describe complete sensorimotor transformations.

Protonic ceramic fuel cells use oxide electrolytes with high protonic conductivity but suffer from low power densities due to sluggish oxygen reduction kinetics and high contact resistances. Here the authors integrate a PrBa_0.5Sr_0.5Co_1.5Fe_0.5O_5+δ cathode and a BaZr_0.4Ce_0.4Y_0.1Yb_0.1O₃ electrolyte, achieving exceptional power density and stability.

Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.

T cell clonal anergy is mediated by Egr2 but its downstream effectors have not been characterized. Here the authors show that Egr2 activates Ndrg1, which is critical for the anergy state, while anergy-counteracting signals IL-2 or CD-28 promote Ndrg1 phosphorylation and degradation.

Hardware implementation of spiking neural networks holds promise for high energy efficient brain-inspired computing. Here, Prezioso et al. realize the detection of synchrony in a demo circuit composed of 20 metal-oxide memristor synapses connected to a leaky-integrate-and-fire silicon neuron.

Fevers are known to be both beneficial and detrimental in disease, but the fundamental innate immune mechanisms driving pathology in this context remain unclear. Here, the authors show that a combination of LPS and heat stress induces inflammatory cell death, PANoptosis, that is dependent on the executioner molecule Ninjurin 1 (Ninj1) to release inflammatory molecules and drive pathogenesis.

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

Segmentation accuracy of serial section electron microscopy (ssEM) images can be limited by the step of aligning 2D section images to create a 3D image stack. Here the authors report a computational pipeline for aligning ssEM images and apply this to a whole fly brain dataset.

In an interim analysis of a phase 1/2 trial, a heterologous prime boost vaccine comprised of a chimpanzee adenovirus and self-amplifying mRNA that encodes neoantigens derived from common oncogenic driver mutations in combination with immune checkpoint blockade was safe and elicited neoantigen-specific T cell responses in patients with advanced solid tumors.