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Showing 51–100 of 547 results

Advanced filters: Author: D. Frail Clear advanced filters

Dentists’ opinions on knowledge, attitudes and barriers in providing oral health care to older people living independently in the Netherlands and Flanders (Belgium)

P C Bots-VantSpijker
J J M Bruers
J M G A Schols
ResearchOpen Access22 Dec 2017
BDJ Open

Volume: 3, P: 1-8
Observational study of frailty in older Japanese patients with non-valvular atrial fibrillation receiving anticoagulation therapy

Kunihiko Matsui
Kengo Kusano
Hisao Ogawa
ResearchOpen Access22 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
High continuity of forager ancestry in the Neolithic period of the eastern Maghreb

Ancient DNA from the eastern Maghreb (Tunisia and Algeria) dating between 15,000 and 6,000 years ago shows that this region was far less affected by external gene flow than the rest of the Neolithic Mediterranean, including not only Europe but also the western Maghreb (Morocco).

Mark Lipson
Harald Ringbauer
David Reich
Research12 Mar 2025
Nature

Volume: 641, P: 925-931
Epidemiology and transmission dynamics of multidrug-resistant organisms in nursing homes within the United States

Nursing homes are high-risk settings for transmission of infections, but risks associated with specific activities are not well understood. Here, the authors investigate transmission dynamics of multi-resistant organisms in nursing homes in the United States with a focus on out-of-room, interactive visits.

Lona Mody
Kristen E. Gibson
Robin L. P. Jump
ResearchOpen Access13 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Longitudinal effects of a common UMOD variant on kidney function, blood pressure, cognitive and physical function in older women and men

Engi Abdel–Hady Algharably
Linda Elizabeth Villagomez Fuentes
Reinhold Kreutz
ResearchOpen Access28 Nov 2022
Journal of Human Hypertension

Volume: 37, P: 709-717
Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis

Eva Román
Maria Poca
German Soriano
ResearchOpen Access14 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease

Ayumi Fukatsu-Chikumoto
Tsunahiko Hirano
Kazuto Matsunaga
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation

L. Lopez-Corral
C. Blázquez-Goñi
JA Pérez-Simón
ResearchOpen Access08 Apr 2025
Bone Marrow Transplantation

Volume: 60, P: 832-840
The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East

Seyedeh Zahra Badrkhahan
Moein Ala
Ramin Heshmat
ResearchOpen Access31 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Lump, lump-periodic, lump-soliton and multi soliton solutions for the potential Kadomtsev-Petviashvili type coupled system with variable coefficients

Haiwei Chen
Jalil Manafian
A. SA. Alsubaie
ResearchOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1-20
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

Here, Swarte et al. use metagenomics to investigate the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients, showing evidence for the association of multiple taxonomic, metabolic and neuroactive pathways (gut brain modules) with lower HRQoL, together suggesting potential modifiable gut microbial factors to improve HRQoL.

J. Casper Swarte
Tim J. Knobbe
Rinse K. Weersma
ResearchOpen Access02 Dec 2023
Nature Communications

Volume: 14, P: 1-11
Senolytics improve physical function and increase lifespan in old age

Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.

Ming Xu
Tamar Pirtskhalava
James L. Kirkland
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1246-1256
Composite diagnostic criteria are problematic for linking potentially distinct populations: the case of frailty

Yi-Sheng Chao
Chao-Jung Wu
Wei-Chih Chen
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Refeeding-associated AMPK_γ1 complex activity is a hallmark of health and longevity

Age impacts the effect of dietary health and longevity interventions but the underlying mechanisms are incompletely understood. Here the authors study fasting in killifish and find that older animals exhibit a metabolic shift resembling a fasting-like program, which is counteracted by boosting the activity of AMPKγ1, promoting health and longevity.

Roberto Ripa
Eugen Ballhysa
Adam Antebi
ResearchOpen Access13 Nov 2023
Nature Aging

Volume: 3, P: 1544-1560
Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial

Molecular effects of lifestyle interventions are typically studied within one tissue, neglecting potential shared responses across tissues. Here, the authors show that subcutaneous adipose tissue RNA levels best capture health benefits of the intervention and identified joint effects among blood, subcutaneous adipose tissue and muscle tissue RNA levels.

F. A. Bogaards
T. Gehrmann
P. E. Slagboom
ResearchOpen Access15 Aug 2024
Nature Communications

Volume: 15, P: 1-18
The rarity of soft γ-ray repeaters deduced from reactivation of SGR1806 – 20

C. Kouveliotou
G. J. Fishman
D. A. Green
Research10 Mar 1994
Nature

Volume: 368, P: 125-127
An association between a long-period pulsar and an old supernova remnant

S. R. Kulkarni
P. Predehl
B. Aschenbach
Research11 Mar 1993
Nature

Volume: 362, P: 135-137
Quantitative analysis of pathological findings identified clinical heterogeneity in nonspecific interstitial pneumonia with organising pneumonia overlap

Masato Asaoka
Hideya Kitamura
Takashi Ogura
ResearchOpen Access03 Jun 2025
Scientific Reports

Volume: 15, P: 1-13
Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study

Takashi Niwa
Chisato Saeki
Akihito Tsubota
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
An explorative study on movement detection using wearable sensors in acute care hospital patients

Joris Kirchberger
Dominik Kunz
Jens Eckstein
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-9
Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN)

Alessandra Larocca
Sandra Maria Dold
Monika Engelhardt
Reviews25 Apr 2018
Leukemia

Volume: 32, P: 1697-1712
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Huaxi Xu
Gunnar K. Gouras
Sam Gandy
Research01 Apr 1998
Nature Medicine

Volume: 4, P: 447-451
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

Wolfgang Driever
Gudrun Thoma
Christiane Nüsslein-Volhard
Research03 Aug 1989
Nature

Volume: 340, P: 363-367
Importance analysis of psychosociological variables in frailty syndrome in heart failure patients using machine learning approach

Aleksandra Helena Pasieczna
Remigiusz Szczepanowski
Anant Dixit
ResearchOpen Access13 May 2023
Scientific Reports

Volume: 13, P: 1-12
Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection

Gianmaria Mancioppi
Laura Fiorini
Filippo Cavallo
ResearchOpen Access02 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Aging and putative frailty biomarkers are altered by spaceflight

Andrea Camera
Marshall Tabetah
Afshin Beheshti
ResearchOpen Access11 Jun 2024
Scientific Reports

Volume: 14, P: 1-21
Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Integration of longitudinal single-cell analysis of relapsed and refractory multiple myeloma patients in a prospective clinical trial uncovers new pathways of drug resistance and identifies potential actionable targets.

Yael C. Cohen
Mor Zada
Ido Amit
Research22 Feb 2021
Nature Medicine

Volume: 27, P: 491-503
Genesis of a pulsar's planets

R. A. M. J. WIJERS
E. P. J. VAN DEN HEUVEL
D. BHATTACHARYA
Research13 Feb 1992
Nature

Volume: 355, P: 593
Changes in long-term life expectancy and years of life lost following the Great East Japan Earthquake in Fukushima Prefecture

Makoto Kosaka
Hiroaki Saito
Masaharu Tsubokura
ResearchOpen Access14 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Resonant orbital evolution in the putative planetary system of PSR1257 + 12

R. Malhotra
D. Black
A. Jackson
Research16 Apr 1992
Nature

Volume: 356, P: 583-585
Conservative versus operative treatment of FFP II fractures in a geriatric cohort: a prospective randomized pilot trial

Darius M. Thiesen
Gerrit Althoff
Maximilian J. Hartel
ResearchOpen Access26 Sept 2023
Scientific Reports

Volume: 13, P: 1-9
Factors related to sex differences in long-term functional decline after acute ischemic stroke

Fumi Irie
Kuniyuki Nakamura
Takuya Kiyohara
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results

Interim results from the low-dose cohort of the PROCLAIM trial show that AAV-based delivery of the progranulin gene in patients with frontotemporal dementia was safe and was associated with increased CSF progranulin.

Jeffrey Sevigny
Olga Uspenskaya
Franz Hefti
ResearchOpen Access14 May 2024
Nature Medicine

Volume: 30, P: 1406-1415
Unusual interaction of the high-velocity pulsar PSR1757–24 with the supernova remnant G5.4–1.2

D. A. Frail
S. R. Kulkarni
Research29 Aug 1991
Nature

Volume: 352, P: 785-787
High throughput screening of mitochondrial bioenergetics in human differentiated myotubes identifies novel enhancers of muscle performance in aged mice

Nadine Biesemann
Janina S. Ried
Carsten Strübing
ResearchOpen Access20 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
An eclipsing millisecond pulsar in the globular cluster Terzan 5

A. G. Lyne
R. N. Manchester
D. Frail
Research18 Oct 1990
Nature

Volume: 347, P: 650-652
Antibody–drug conjugates come of age in oncology

Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of cytotoxic agents. The technology to develop these agents has improved in past years, but toxicity remains a key issue. This Review provides a broad overview of the recent advances and challenges in ADC development for cancer treatment.

Charles Dumontet
Janice M. Reichert
Alain Beck
Reviews12 Jun 2023
Nature Reviews Drug Discovery

Volume: 22, P: 641-661
International myeloma working group immunotherapy committee recommendation on sequencing immunotherapy for treatment of multiple myeloma

Luciano J. Costa
Rahul Banerjee
Ajai Chari
ReviewsOpen Access27 Jan 2025
Leukemia

Volume: 39, P: 543-554
A roadmap towards improving outcomes in multiple myeloma

Mohamad Mohty
Thierry Facon
Jean-Luc Harousseau
ReviewsOpen Access12 Aug 2024
Blood Cancer Journal

Volume: 14, P: 1-4
Identification of a host galaxy at redshift z = 3.42 for the γ-ray burst of 14 December 1997

S. R. Kulkarni
S. G. Djorgovski
J. Newman
Research07 May 1998
Nature

Volume: 393, P: 35-39
Predicting progression events in multiple myeloma from routine blood work

Maximilian Ferle
Nora Grieb
Maximilian Merz
ResearchOpen Access30 Apr 2025
npj Digital Medicine

Volume: 8, P: 1-15
Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

There is a need for an accurate measure of pulmonary oxygenation function that can be used as an intermediate endpoint in pragmatic clinical trials, to increase statistical power and efficiency. Here, the authors show that the S/F94, a modification of the S/F ratio, is a simple, meaningful and effective intermediate outcome measure.

Maaike C. Swets
Steven Kerr
J. Kenneth Baillie
ResearchOpen Access15 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Inequalities in healthcare use during the COVID-19 pandemic

An indirect impact of the COVID-19 pandemic was a decline in healthcare utilisation for other conditions. Here, the authors quantify this decline in the Netherlands and show that impacts were greater for individuals with lower household income, females, older people, and those with a migrant background.

Arun Frey
Andrea M. Tilstra
Mark D. Verhagen
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-9
Clinical features and prognosis of COVID-19 in people with spinal cord injury: a case–control study

S. D’Andrea
O. Berardicurti
A. Barbonetti
Research04 Aug 2020
Spinal Cord Series and Cases

Volume: 6, P: 1-6
Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa

Emergence of the Omicron BA.1/2 SARS-CoV-2 subvariants led to a wave of infection South Africa. Here, the authors use serological data from a prospective household study to characterise infection rates in the context of diverse immune histories following vaccination and exposure to different variants.

Kaiyuan Sun
Stefano Tempia
Floidy Wafawanaka
ResearchOpen Access16 Jan 2023
Nature Communications

Volume: 14, P: 1-13
Visual impairment in elderly patients with hip fracture: causes and associations

A Cox
A Blaikie
R Sanders
Research27 Aug 2004
Eye

Volume: 19, P: 652-656
Steatotic liver disease is a marker of multimorbidity, not underlying cirrhosis, in older adults

O. Oduwole
C. Ding
A. Britton
ResearchOpen Access05 May 2025
npj Gut and Liver

Volume: 2, P: 1-9
Frailty: A cost incurred by reproduction?

E. H. Gordon
N. M. Peel
R. E. Hubbard
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Reversible mitochondrial stress leading to improved mitochondrial function (mitohormesis) has been reported as an anti-aging mechanism. Here the authors report that harmol (a beta-carboline compound) induces mitohormesis in peripheral organs, alleviates aging-related phenotypes in mice, and extends lifespan in invertebrate models.

Luis Filipe Costa-Machado
Esther Garcia-Dominguez
Pablo J. Fernandez-Marcos
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-22
Preoperative handgrip strength is not associated with complications and health-related quality of life after surgery for colorectal cancer

M. van Heinsbergen
J. L. Konsten
M. L. Janssen-Heijnen
ResearchOpen Access03 Aug 2020
Scientific Reports

Volume: 10, P: 1-8

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