Tissues of the central nervous system (CNS) can be functionally modelled using cell biology-based and engineering-based strategies to allow the study of CNS mechanisms, function and pathology in vitro. This Review discusses the design of bioengineered CNS models, highlighting how customizable tissues can enable a mechanistic deconvolution of complex CNS functions.
- Nicolas Rouleau
- Nirosha J. Murugan
- David L. Kaplan