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Advanced filters: Author: Dah-eun Chloe Chung Clear advanced filters

  • Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.

    • Jiyoen Kim
    • Bakhos Tadros
    • Huda Yahya Zoghbi
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2417-2429