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SARS-CoV-2 infection establishes a stable and age-independent CD8⁺ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Although SARS-CoV2 epitope characterization has been the focus of extensive research, these efforts have largely focused on the spike protein. Here, the authors demonstrate that CD8⁺ T cell responses can be directed against a dominant nucleocapsid epitope and rely on a highly focused T cell receptor repertoire.

Cecily Choy
Joseph Chen
Nan-Ping Weng
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-19
Enhanced ultrasound particle image velocimetry (E-uPIV) enables fast flow mapping of microvasculature

Ultrasound particle image velocimetry (uPIV) is widely used for blood flow measurement but is limited by the diffraction limit. Jingyi Yin, Jiabin Zhang, Jue Zhang and colleagues propose enhanced ultrasound particle image velocimetry (EuPIV), which enables dynamic microflow imaging with higher spatial resolution.

Jingyi Yin
Jiabin Zhang
Jue Zhang
ResearchOpen Access14 May 2025
Communications Engineering

Volume: 4, P: 1-13
Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice

Decreased host glucose levels upon Yersinia pseudotuberculosis infection activate AMPK, leading to RIPK1 inhibition and suppression of pyroptosis to exacerbate disease outcomes in mice.

Yuanxin Yang
Hongwen Fang
Daichao Xu
Research06 Jun 2024
Nature Microbiology

Volume: 9, P: 2144-2159
The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren
Moshi Song
Guang-Hui Liu
Correspondence19 Jul 2023
Nature Medicine

Volume: 29, P: 2162-2165
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

Xu and colleagues identify a sequential palmitoylation–depalmitoylation mechanism that controls GSDMD cleavage by caspases, plasma membrane trafficking and oligomerization, thereby triggering pyroptosis in a spatial and temporal manner.

Na Zhang
Jian Zhang
Daichao Xu
Research27 Mar 2024
Nature Cell Biology

Volume: 26, P: 757-769
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. Here the authors report that a SUMO-specific protease, SENP1, deSUMOylates RIPK1 and inhibits cell death in a mouse model of non-alcoholic fatty liver disease.

Lingjie Yan
Tao Zhang
Daichao Xu
ResearchOpen Access22 Nov 2022
Nature Communications

Volume: 13, P: 1-19
UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis

The mechanism underlying hepatocytes apoptosis, a key process in the progression of nonalcoholic steatohepatitis, remains unclear. Here, the authors identify UGDH and its catalytic product UDP-glucuronate as suppressors of NASH-associated liver damage by inhibiting RIPK1- dependent hepatocyte apoptosis.

Tao Zhang
Na Zhang
Jinyang Gu
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-18
A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems

Xiaochun Yang
Daichao Chen
Yang Zhao
ResearchOpen Access06 Jun 2023
Cell Discovery

Volume: 9, P: 1-26
Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Jun Wei
Min Li
Yunhong Zha
ResearchOpen Access13 Dec 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-8

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SARS-CoV-2 infection establishes a stable and age-independent CD8⁺ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Enhanced ultrasound particle image velocimetry (E-uPIV) enables fast flow mapping of microvasculature

Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice

The Aging Biomarker Consortium represents a new era for aging research in China

A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis

A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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