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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research13 Feb 2023
Nature Immunology

Volume: 24, P: 412-413
A STIM2 splice variant negatively regulates store-operated calcium entry

STIM proteins sense calcium depletion in the endoplasmic reticulum and in response activate calcium influx through Orai1 channels located at the plasma membrane. Here, Miederer et al. identify a novel splice variant of STIM2 that fails to interact with and activate Orai1 and may act to fine-tune cellular calcium homeostasis by negatively regulating calcium influx.

Anna-Maria Miederer
Dalia Alansary
Barbara A. Niemeyer
ResearchOpen Access21 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Thiol dependent intramolecular locking of Orai1 channels

Dalia Alansary
Barbara Schmidt
Barbara A. Niemeyer
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.

Lukas Bunse
Stefan Pusch
Michael Platten
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1192-1203
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Overabundance of apolipoprotein C3 (ApoC3) is associated with atherosclerosis. Speer and colleagues demonstrate that ApoC3 activates the NLRP3 inflammasome via a non-canonical pathway contributing to inflammation and development of atherosclerosis.

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research09 Dec 2019
Nature Immunology

Volume: 21, P: 30-41
Modulation of intracellular calcium signaling by microRNA-34a-5p

Caroline Diener
Martin Hart
Eckart Meese
ResearchOpen Access27 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-13

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

A STIM2 splice variant negatively regulates store-operated calcium entry

Thiol dependent intramolecular locking of Orai1 channels

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Modulation of intracellular calcium signaling by microRNA-34a-5p

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