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Showing 1–50 of 14901 results
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  • How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

    • Jing Cai
    • Alex E. Hadjinicolaou
    • Sydney S. Cash
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The ribosomal decoding center monitors accurate translation of 3-base mRNA codons. Here, the authors use cryo-EM to show how one of the monitoring bases of the ribosome enables a frameshift-inducing tRNA to instead read a 2-base codon.

    • Shruthi Krishnaswamy
    • Shirin Akbar
    • Maria Selmer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-6
  • Improving neuraminidase content of influenza vaccines is a major focus of vaccine development. Here the authors present safety and immunogenicity of seasonal influenza mRNA vaccine candidates simultaneously encoding hemagglutinin and neuraminidase antigens in a first in-human study.

    • Amanda K. Rudman Spergel
    • Ivan T. Lee
    • Raffael Nachbagauer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Current models suggest that DLK1 is an inhibitory ligand in the Notch pathway. Here, the authors show that DLK1 does not interact with Notch receptors, instead blocking Activin signaling via an interaction with Activin receptor type-2B.

    • Daniel Antfolk
    • Qianqian Ming
    • Vincent C. Luca
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature exposure and cell types.

    • Emily Mitchell
    • My H. Pham
    • Michael R. Stratton
    ResearchOpen Access
    Nature Genetics
    P: 1-11
  • Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

    • Viktoria Cologna
    • Simona Meiler
    • Amber Zenklusen
    ResearchOpen Access
    Nature Climate Change
    Volume: 15, P: 725-735
  • Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

    • Tian Chen Zeng
    • Leonid A. Vyazov
    • David Reich
    Research
    Nature
    P: 1-11
  • Species synchrony is considered a major mechanism of biodiversity–ecosystem stability relationships. Here, by combining theory, modelling and empirical work, the authors show that with time series length species synchrony decreases and its relationship with diversity switches from positive to negative.

    • Mingyu Luo
    • Lauren M. Hallett
    • Shaopeng Wang
    Research
    Nature Ecology & Evolution
    P: 1-9
  • Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

    • Jay J. Van Bavel
    • Aleksandra Cichocka
    • Paulo S. Boggio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • Ambient air pollution exposure in early childhood has been linked to infection risk but the mechanism is unclear. Here, the authors investigate the association between air pollution-linked proteomic profiles in pregnancy and infection in early childhood using data from Denmark and Sweden.

    • Nicklas Brustad
    • Tingting Wang
    • Bo Chawes
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

    • Camille S. Delavaux
    • Thomas W. Crowther
    • Daniel S. Maynard
    ResearchOpen Access
    Nature
    Volume: 621, P: 773-781
  • The study shows a significant gender gap in scholarly self-promotion on Twitter, finding that women are about 28% less likely to promote their own academic papers compared to men, a disparity which is even more pronounced among highly productive women at prestigious institutions. Women’s self-promotion efforts tend to yield fewer overall mentions and visibility online compared to men, highlighting systematic gender biases in digital scholarly communication.

    • Hao Peng
    • Misha Teplitskiy
    • Emőke-Ágnes Horvát
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Colobomatous microphthalmia often lacks a genetic diagnosis despite its developmental complexity. Here, the authors show that rare variants in NR6A1 cause a syndromic form with eye, kidney, and vertebral defects, supported by zebrafish functional validation.

    • Uma M. Neelathi
    • Ehsan Ullah
    • Brian P. Brooks
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • This study in the Finnish population reveals genetic reduction of the complement factor CFHR5 as enhancing retinal health and reducing the risk for age-related macular degeneration (AMD), suggesting new strategies for AMD prevention and treatment.

    • Mary Pat Reeve
    • Stephanie Loomis
    • Heiko Runz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Whether neurocomputational mechanisms that speed up human learning in changing environments also exist in other species remains unclear. Here, the authors show that both rats and humans sequentially test different abstract hypotheses to infer rules.

    • Florian Bähner
    • Tzvetan Popov
    • Daniel Durstewitz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Efficient sunlight-to-fuel conversion requires materials that produce long-lived charges, but increasing carrier lifetimes in visible-light-active photocatalysts has proven difficult. Now it has been shown that rapid charge deactivation via metal-centred states prevents long lifetimes and limits photocatalytic performance. These insights bridge solid-state and molecular photochemistry, informing strategies for improved photocatalyst design.

    • Michael Sachs
    • Liam Harnett-Caulfield
    • James R. Durrant
    ResearchOpen Access
    Nature Chemistry
    P: 1-8
  • Single-cell transcriptomes from the fetal–maternal interface of six species of mammals reveal a conserved gene expression signature of invasive trophoblast, stepwise evolution of decidual stromal cell types and co-evolutionary patterns in cell–cell signalling.

    • Daniel J. Stadtmauer
    • Silvia Basanta
    • Günter P. Wagner
    ResearchOpen Access
    Nature Ecology & Evolution
    P: 1-18
  • High-resolution satellite data enables a unique verification of national methane emissions worldwide. Global estimates are 63 Tg a−1 for oil-gas, 30% higher than the UNFCCC reports due to under-reporting by four largest emitters, and 33 Tg a−1 for coal, consistent with previous estimates.

    • Lu Shen
    • Daniel J. Jacob
    • Jintai Lin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9
  • Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing surface protein expression across large and heterogeneous datasets.

    • Ye Zheng
    • Daniel P. Caron
    • Raphael Gottardo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • R2 retrotransposons are natural RNA guided gene insertion systems. Here, Edmonds et al. characterize the structure and biochemistry of an avian R2 and engineer a compact, all-RNA system to integrate DNA in mammalian cells, aiding the development of future retrotransposon-based gene editors.

    • KeHuan K. Edmonds
    • Max E. Wilkinson
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Ethnic disparities in severe outcomes of COVID-19 were observed from early in the pandemic. Here, the authors investigate whether differences in mortality and cardiovascular disease outcomes persisted until 2.5 years after the start of the pandemic using electronic health record data from England and Wales.

    • Marta Pineda-Moncusí
    • Freya Allery
    • Sara Khalid
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

    • Flavia W. de Faria
    • Nicole C. Riedel
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Two BCMA-targeted CAR T products, idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), have been approved for the treatment of multiple myeloma (MM). Here the authors report distinct expansion, phenotype, function, and toxicity of cilta-cel vs. ide-cel CAR T cells in a realworld cohort of patients with MM.

    • Djordje Atanackovic
    • Tim Luetkens
    • Mehmet H. Kocoglu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

    • Maria Koromina
    • Ashvin Ravi
    • Niamh Mullins
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 1393-1403
  • Down syndrome causes extensive Alzheimer’s disease pathology in all individuals and has been instrumental in development of the amyloid hypothesis in AD. Here, the authors use proteomics on Down syndrome spinal fluid and brain tissues to illustrate the common and unique changes in DSAD compared to other genetic forms of AD and the more common late-onset form of the disease.

    • Laia Montoliu-Gaya
    • Shijia Bian
    • Erik C. B. Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Parametric matrix models (PMMs) are a new class of machine learning methods using parametrized matrices to find implicit governing equations describing data. PMMs excel at making accurate predictions for scientific computing applications.

    • Patrick Cook
    • Danny Jammooa
    • Dean Lee
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • A phenomenological model using electronegativity, ionic size, and charge predicts layered cation-eutaxy structures in ternary compounds. Experimental validation supports the model’s reliability and highlights its potential for guiding future materials discovery.

    • Jongbum Won
    • Taeyoung Kim
    • Wooyoung Shim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Aneuploidy disrupts proteostasis, leading to protein aggregation and accumulation of SQSTM1/p62 in the cytosol. Here, the authors show that cytosolic p62-positive bodies in aneuploid cells are enriched for mitochondrial precursor proteins, which in turn impairs mitochondrial function.

    • Prince Saforo Amponsah
    • Jan-Eric Bökenkamp
    • Zuzana Storchová
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • The authors demonstrate mitigation of both chromatic and modal dispersion in multimode optical fibers via spatiotemporal tailoring of ultrashort light pulses. This holds potential for applications such as in multimode imaging, long-distance communications, ultrafast light-matter interactions, optical fiber amplifiers, and multidimensional information encoding.

    • Daniel Cruz-Delgado
    • J. Enrique Antonio-Lopez
    • Rodrigo Amezcua-Correa
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • National parochialism is the tendency to cooperate more with people of the same nation. In a 42-nations study, the authors show that national parochialism is a pervasive phenomenon, present to a similar degree across all the studied nations, and occurs both when decisions are private or public.

    • Angelo Romano
    • Matthias Sutter
    • Daniel Balliet
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8
  • Therapeutic T cells engineered to recognize tumour antigens are frequently short-lived and acquire unfavourable phenotypes in tumours. Here authors show that a tandem approach using autologous T cells targeted against the tumour antigen NY-ESO-1, followed by transfer of hematopoietic stem cells with the same specificity in the clinical trial NCT03240861, provides a safe and promising therapeutic option.

    • Theodore S. Nowicki
    • Nataly Naser Al Deen
    • Antoni Ribas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Mesocosm experiments revealed that both phytoplankton community composition and cellular acclimation influence marine particulate C:N:P ratios, with community shifts more sensitive to nitrogen supply and acclimation to the nutrient N:P supply ratio

    • Emily A. Seelen
    • Samantha J. Gleich
    • Seth G. John
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Relapsed and/or refractory acute myeloid leukemia (AML) postallogeneic hematopoietic cell transplantation has limited treatment options. Here the authors report the clinical results and immune correlates of a phase I/II trial of adoptively transferred virus-specific donor CD8 + T cells engineered to express a WT1-specific T cell receptor in patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation.

    • Francesco Mazziotta
    • Lauren E. Martin
    • Aude G. Chapuis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Fas ligand (FasL) regulates immunotherapeutic cancer-cell death. Here, the authors show a human-specific amino-acid substitution which renders human FasL more susceptible for plasmin cleavage and is relevant for the efficacy of T-cell-based immunotherapies.

    • Brice E. N. Wamba
    • Tanmoy Mondal
    • Jogender Tushir-Singh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • Clarke et al. identify chromatin factor ZNF280A, which is recruited to damaged chromatin where it promotes long-range DNA-end resection. Loss of ZNF280A is linked to genome instability in patients with 22q11.2 distal deletion syndrome.

    • Thomas L. Clarke
    • Hyo Min Cho
    • Raul Mostoslavsky
    Research
    Nature Cell Biology
    Volume: 27, P: 1006-1020
  • Mutations in mtDNA contribute to mitochondrial disease and aging only if they rise in abundance. Here, the authors show that deleterious mutations reach high abundance by hitchhiking on genomes that have a replicative advantage.

    • Ekaterina Korotkevich
    • Daniel N. Conrad
    • Patrick H. O’Farrell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • The development of microelectronics requires precursors that can deposit conductive features, however Al is normally deposited using pyrophoric AlH3 etherates/aminates. Here, the authors use ligands to impart stability and report an aluminium complex that can undergo conversion to Al(0) at 100 °C.

    • Erica N. Faria
    • Samuel P. Douglas
    • Caroline E. Knapp
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7