Nature Search

The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response

Rafal Rozalski
Daniel Gackowski
Ryszard Olinski
ResearchOpen Access01 Nov 2021
Scientific Reports

Volume: 11, P: 1-12
Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome

Igor A. Yakovlev
Daniel Gackowski
Konstantin V. Krutovsky
ResearchOpen Access17 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Dynamic changes in genomic 5-hydroxymethyluracil and N6-methyladenine levels in the Drosophila melanogaster life cycle and in response to different temperature conditions

Marta Starczak
Maciej Gawronski
Daniel Gackowski
ResearchOpen Access20 Oct 2022
Scientific Reports

Volume: 12, P: 1-13
N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

N⁶-methyladenosine (m⁶A) is prevalent at RNA:DNA hybrids in human pluripotent stem cells. The m⁶A reader YTHDF2 interacts with R-loop-enriched loci in dividing cells, and YTHDF2 loss leads to increased R-loop levels and accumulation of γH2AX.

Abdulkadir Abakir
Tom C. Giles
Alexey Ruzov
Research16 Dec 2019
Nature Genetics

Volume: 52, P: 48-55
The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

Kinga Linowiecka
Jolanta Guz
Marek Foksiński
ResearchOpen Access18 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.

Martin J. Blythe
Ayhan Kocer
Alexey Ruzov
ResearchOpen Access07 Jun 2021
Communications Biology

Volume: 4, P: 1-11
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Using TET2- and ascorbic acid deficient model systems Guan et al show that long term treatment with ascorbic acid delays myeloid neoplasia in mice and reveal a complex interplay of post-translational modification of lysine residues that modulate TET2 activity in neoplastic evolution.

Yihong Guan
Edward F. Greenberg
Babal K. Jha
ResearchOpen Access07 Sept 2020
Communications Biology

Volume: 3, P: 1-13

Search

The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response

Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome

Dynamic changes in genomic 5-hydroxymethyluracil and N6-methyladenine levels in the Drosophila melanogaster life cycle and in response to different temperature conditions

N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Search

Quick links

Search

Filter By:

The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response

Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome

Dynamic changes in genomic 5-hydroxymethyluracil and N6-methyladenine levels in the Drosophila melanogaster life cycle and in response to different temperature conditions

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Search

Quick links

N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells