Search

Mercury’s exosphere is known to predominately contain hydrogen, helium, sodium, potassium, calcium, magnesium, aluminum, iron, and manganese. Here, the authors show evidence of the presence of lithium (Li) in the exosphere of Mercury, most likely originating from meteoroids.

The study shows a significant gender gap in scholarly self-promotion on Twitter, finding that women are about 28% less likely to promote their own academic papers compared to men, a disparity which is even more pronounced among highly productive women at prestigious institutions. Women’s self-promotion efforts tend to yield fewer overall mentions and visibility online compared to men, highlighting systematic gender biases in digital scholarly communication.

Analysis of data from multiple instruments reveals a giant exoplanet in orbit around the 0.2-solar-mass star TOI-6894. The existence of this exoplanetary system challenges assumptions about planet formation and it is an excellent target for atmospheric characterization.

Ambient air pollution exposure in early childhood has been linked to infection risk but the mechanism is unclear. Here, the authors investigate the association between air pollution-linked proteomic profiles in pregnancy and infection in early childhood using data from Denmark and Sweden.

European Commission's former chief scientific adviser, Anne Glover, also among those honoured by the Queen.

Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

Natural compounds produced by the world's microbes were once the go-to source of molecules for the drug industry before the chemistry dried up and big pharma went packing. Now, researchers hope that advances in genomics will bring companies back into the fold. Daniel Grushkin visits one startup hoping to accelerate the process.

Cellular senescence drives aging, with the p53–FOXO4 axis sustaining senescent cell viability. This study reveals structural insights into p53 binding to FOXO4/FOXO4-DRI, informing the development of p53-targeted senolytics for age related diseases.

Interferometric detection schemes exploit phase-sensitive combination of spatially separated observation to increase sensitivity. Here, the authors combine data from two atomic comagnetometers separated by 860 km to improve limits on axion-like particles across nine orders of magnitude of mass range.

A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

London Declaration attempts to stem slaughter of wildlife.

Politicians take action on poaching in Africa as tusk seizures approach record numbers.

In the primary report of a phase 1b trial, adeno-associated virus gene therapy with fordadistrogene movaparvovec in patients with Duchenne muscular dystrophy was well tolerated in an ambulatory cohort, and mini-dystrophin expression was increased in the high-dose cohort.

Atomically thin layers of a correlated topological semimetal exhibit a nonlinear Hall effect that can be used to fabricate terahertz photodetectors with a room-temperature responsivity of 0.3 A W⁻¹, a broadband terahertz range and a picosecond response time.

Relapsed and/or refractory acute myeloid leukemia (AML) postallogeneic hematopoietic cell transplantation has limited treatment options. Here the authors report the clinical results and immune correlates of a phase I/II trial of adoptively transferred virus-specific donor CD8 + T cells engineered to express a WT1-specific T cell receptor in patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation.

Case brought by Mohamed El Naschie dismissed, but campaigners say it proves need for libel reform.

Clean cooking fuels can be unaffordable. A year-long randomized control trial in Tanzania finds that a lockbox intervention along with behavioural nudging to encourage savings modestly increased liquefied petroleum gas use but did not lead to exclusive adoption, and that gendered financial constraints explain these results.

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Retarder arrays enable advanced photonic applications but are limited by controllable flexibility. Here, authors demonstrate a compound modulator that creates synthetic tuneable retarder arrays, offering unprecedented dynamic control of light, enabling new beam generation, analysis, and correction.

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Current intracortical brain-computer interfaces are subject to recording interface instabilities that degrade decoding performance. Here, the authors present a platform for Nonlinear Manifold Alignment with Dynamics (NoMAD), which stabilizes decoding using models of dynamics for at least 3 months.

In patients with advanced cancer, the development of brain metastasis (BM) often signals a worsening prognosis with limited therapeutic options. Here, the authors assemble a large, open-source neuroimaging dataset of BM and perform spatial and morphological analysis which they use to develop a framework for function-sparing brain radiotherapy design.

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

This genetic study utilizing the newest available GWAS summary statistics provides evidence on the relationship between cannabis use, cannabis use disorder and a range of psychiatric disorders.

In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more than 21,000 monozygotic twins—the largest genetic study of monozygotic twin differences to date.

Trees come in all shapes and size, but what drives this incredible variation in tree form remains poorly understood. Using a global dataset, the authors show that a combination of climate, competition, disturbance and evolutionary history shape the crown architecture of the world’s trees and thereby constrain the 3D structure of woody ecosystems.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Dinoflagellates and cyanobacteria produce saxitoxin (STX) congeners that block voltage-gated sodium channels. Here authors show how amphibians may sequester STX congeners using a ‘lock and key’ mode, expanding the understanding of toxic sponge action.

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

As presented at the 2025 ASCO Annual Meeting, intracerebroventricular infusion of bivalent CAR T cells targeting EGFR and IL-13Rα2 in patients with multifocal, recurrent glioblastoma was feasible and well tolerated, with the maximum tolerated dose identified, one patient with a partial response and one patient with durable stable disease.

Increasing rates of multidrug-resistant bacterial infections has renewed interest in the therapeutic use of phages. Here the authors report an individual with cutaneous M. chelonae infection, and the improvement of disease upon treatment with a bacteriophage in combination with antimicrobial therapy.

To investigate inequalities in energy access, Kersey and co-authors conducted a mixed-method study with 25 informal settlements in Kampala, Uganda. They found that despite the expansion of electrical grids in Sub-Saharan Africa, users are connecting to the grid through a range of service arrangements that are highly differentiated and provide inequitable levels of electricity access.

Kitaev interactions on a honeycomb lattice can potentially lead to a quantum spin liquid state. Unfortunately, materials hosting Kitaev interactions also host Heisenberg interactions favouring long range order. Here, Sakrikar, Shen, Poldi and coauthors find that the relative strength of the Heisenberg and Kitaev interactions can be tuned by pressure in Ag₃LiRh₂O₆.

Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates its potential as a biomarker for guiding immune checkpoint blockade.

Acute febrile illness is common in sub-Saharan Africa and causative agents are often unknown. Here, the authors perform metagenomic sequencing on samples from patients with acute febrile illness in Uganda for which no diagnosis was available through routine diagnostic screening.