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Targeting immune–fibroblast cell communication in heart failure

A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling to cardiac fibroblasts, highlighting a role for immunomodulators in targeting cardiac fibrosis.

Junedh M. Amrute
Xin Luo
Kory J. Lavine
Research23 Oct 2024
Nature

Volume: 635, P: 423-433
Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury

Kadyrov et al. reveal that the hypoxia sensing through HIF1A is an important regulator of monocyte-derived macrophage differentiation, which determines the extent of inflammation and cardiac remodeling after injury.

Farid F. Kadyrov
Andrew L. Koenig
Kory J. Lavine
Research21 Oct 2024
Nature Cardiovascular Research

Volume: 3, P: 1337-1355
Non-hematopoietic allograft cells directly activate CD8⁺ T cells and trigger acute rejection: An alternative mechanism of allorecognition

Daniel Kreisel
Alexander S. Krupnick
Bruce R. Rosengard
Research01 Mar 2002
Nature Medicine

Volume: 8, P: 233-239
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage.

Wulf Tonnus
Claudia Meyer
Andreas Linkermann
ResearchOpen Access20 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

High-affinity IL-2Rα expressed by T_regs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding ___domain, and show that it induces IL-2 signalling selectively in NKG2D⁺cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.

Reza Ghasemi
Eric Lazear
Alexander Sasha Krupnick
ResearchOpen Access21 Sept 2016
Nature Communications

Volume: 7, P: 1-15
Diversity of group 1 innate lymphoid cells in human tissues

Colonna and colleagues analyze human ILC1 diversity by scRNA-seq and flow cytometry in various human tissues.

Natalia Jaeger
Alina Ulezko Antonova
Marco Colonna
Research02 Jul 2024
Nature Immunology

Volume: 25, P: 1460-1473
The human heart contains distinct macrophage subsets with divergent origins and functions

Study of macrophage heterogeneity in human hearts reveals a subset of inflammatory macrophages that is associated with cardiac dysfunction in patients with heart failure.

Geetika Bajpai
Caralin Schneider
Kory J. Lavine
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 1234-1245
CCR2 imaging in human ST-segment elevation myocardial infarction

C-C chemokine receptor type 2 (CCR2) is expressed on inflammatory populations of monocytes and macrophages that contribute to heart failure. In this study, Lavine et al. establish the feasibility of CCR2 imaging in patients who have had a myocardial infarction.

Kory J. Lavine
Deborah Sultan
Yongjian Liu
Research21 Sept 2023
Nature Cardiovascular Research

Volume: 2, P: 874-880
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Tom Karlsen and colleagues report a genome-wide association study for primary sclerosing cholangitis, a chronic bile duct disease. They identify susceptibility loci at MST1 and near BCL2L11.

Espen Melum
Andre Franke
Tom H Karlsen
Research12 Dec 2010
Nature Genetics

Volume: 43, P: 17-19
Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology

Alexander S Krupnick
Xue Lin
Daniel Kreisel
Protocols18 Dec 2008
Nature Protocols

Volume: 4, P: 86-93
Interorgan communication networks in the kidney–lung axis

Here, the authors review the current understanding of interorgan crosstalk mechanisms, with a focus on interorgan communication in the kidney–lung axis during acute or chronic disease of the kidney or lung.

Yohei Komaru
Yun Zhu Bai
Andreas Herrlich
Reviews04 Sept 2023
Nature Reviews Nephrology

Volume: 20, P: 120-136
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid

Laneshia K. Tague
Derek E. Byers
Andrew Gelman
Research17 Apr 2019
The Pharmacogenomics Journal

Volume: 20, P: 69-79
Quantitative monitoring of mouse lung tumors by magnetic resonance imaging

Alexander Sasha Krupnick
Vanessa K Tidwell
Joel R Garbow
Protocols05 Jan 2012
Nature Protocols

Volume: 7, P: 128-142

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