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Showing 1–6 of 6 results
Advanced filters: Author: Daniel Strebinger Clear advanced filters

  • R2 retrotransposons are natural RNA guided gene insertion systems. Here, Edmonds et al. characterize the structure and biochemistry of an avian R2 and engineer a compact, all-RNA system to integrate DNA in mammalian cells, aiding the development of future retrotransposon-based gene editors.

    • KeHuan K. Edmonds
    • Max E. Wilkinson
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • CRISPR-mediated genome editing tools are entering the clinic, but concerns remain about the potential immunogenicity of these bacterial-derived proteins. Here, Raghavan et al. engineer two Cas effectors, Cas9 and Cas12, for reduced immunogenicity in vivo while maintaining on-target activity.

    • Rumya Raghavan
    • Mirco J. Friedrich
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Targetable delivery vectors for genetic cargo are needed. Here the authors report a modular platform with separate fusion and targeting components—Delivery to Intended REcipient Cells Through Envelope Design (DIRECTED)—and show cell type-specific delivery.

    • Daniel Strebinger
    • Chris J. Frangieh
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • To develop a bacterial secretion system for cytosolic delivery of therapeutic macromolecules, Chabloz et al. improve an “effectorless” Salmonella strain and combine it with a plasmid modified to boost the secretion of proteins of interest. With this system, they demonstrate efficient translocation of functional DARPins and monobodies into the cytosol of different eukaryotic cells lines and successfully block the paradigmatic RAS pathway.

    • Antoine Chabloz
    • Jonas V. Schaefer
    • Josef M. Penninger
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11