Nature Search

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Single-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show a convergent signature with psychopathology across multiple cell types.

Anna S. Fröhlich
Nathalie Gerstner
Elisabeth B. Binder
ResearchOpen Access03 Sept 2024
Nature Neuroscience

Volume: 27, P: 2021-2032
Dilution of candidates: the case of iron-related genes in restless legs syndrome

Konrad Oexle
Barbara Schormair
Juliane Winkelmann
Research29 Aug 2012
European Journal of Human Genetics

Volume: 21, P: 410-414
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.

Leanne K. Küpers
Claire Monnereau
Janine F. Felix
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-11
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.

Josine L. Min
Gibran Hemani
Caroline L. Relton
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1311-1321
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort

Jessica Becker
Darina Czamara
Johannes Schumacher
Research11 Sept 2013
European Journal of Human Genetics

Volume: 22, P: 675-680
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated with serum urate concentrations and confirm 10 known loci, characterize their associations with gout and include a network analysis suggesting a role for inhibins-activins pathways in regulating urate homeostasis.

Anna Köttgen
Eva Albrecht
Christian Gieger
Research23 Dec 2012
Nature Genetics

Volume: 45, P: 145-154
A mega-analysis of genome-wide association studies for major depressive disorder

Stephan Ripke
Naomi R Wray
Patrick F Sullivan
Research03 Apr 2012
Molecular Psychiatry

Volume: 18, P: 497-511
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.

Herbert Schulz
Ann-Kathrin Ruppert
Sven Cichon
ResearchOpen Access15 Nov 2017
Nature Communications

Volume: 8, P: 1-11
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

Darina Czamara
Elleke Tissink
Elisabeth B. Binder
ResearchOpen Access01 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-11
DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans

Natan Yusupov
Simone Roeh
Elisabeth B. Binder
ResearchOpen Access05 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1510-1520
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

A large-scale multi-cohort association study reveals strong and consistent impacts of birth order on DNA methylation events around the genome, potentially due to changes in placentation, nutrition, and growth factors between first and subsequent pregnancies.

Shaobo Li
Natalia Spitz
Joseph L. Wiemels
ResearchOpen Access09 Jan 2024
Communications Biology

Volume: 7, P: 1-11
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Priyanka Choudhary
Giulietta S. Monasso
Sylvain Sebert
ResearchOpen Access05 Dec 2023
Molecular Psychiatry

Volume: 29, P: 348-358
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Anna Kotsakis Ruehlmann
Sara Sammallahti
Kelly J. Brunst
Research10 Mar 2023
Molecular Psychiatry

Volume: 28, P: 5090-5100
Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

Natan Yusupov
Linda Dieckmann
Elisabeth B. Binder
ResearchOpen Access17 Apr 2023
Neuropsychopharmacology

Volume: 48, P: 1409-1417
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic health outcomes in offspring.

Nora Fernandez-Jimenez
Ruby Fore
Jose Ramon Bilbao
ResearchOpen Access30 Nov 2022
Communications Biology

Volume: 5, P: 1-11
DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder

Sylvain Moser
Jade Martins
Angelika Erhardt
ResearchOpen Access01 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-10
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Doretta Caramaschi
Alexander Neumann
Gemma Sharp
ResearchOpen Access10 Feb 2022
Molecular Psychiatry

Volume: 27, P: 2126-2135
Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease

Sarah Irmscher
Svante L. H. Zipfel
Christine Skerka
ResearchOpen Access18 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

Thomas W. Winkler
Humaira Rasheed
Iris M. Heid
ResearchOpen Access13 Jun 2022
Communications Biology

Volume: 5, P: 1-20
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen
Fiona A. Hagenbeek
Dorret I. Boomsma
ResearchOpen Access08 Jan 2021
Molecular Psychiatry

Volume: 26, P: 2148-2162
Toll-like receptor 4 methylation grade is linked to depressive symptom severity

Annica J. Rasmusson
Maike Gallwitz
Janet L. Cunningham
ResearchOpen Access24 Jun 2021
Translational Psychiatry

Volume: 11, P: 1-9
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Alessandro Gialluisi
Till F. M. Andlauer
Gerd Schulte-Körne
ResearchOpen Access14 Oct 2020
Molecular Psychiatry

Volume: 26, P: 3004-3017
Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Sara Sammallahti
Andrea P. Cortes Hidalgo
Jari Lahti
Research07 Jan 2021
Molecular Psychiatry

Volume: 26, P: 1832-1845
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Alexander Neumann
Esther Walton
Henning Tiemeier
ResearchOpen Access12 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-11
FoxO1, A2M, and TGF-β1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses

Annamaria Cattaneo
Nadia Cattane
Carmine M. Pariante
ResearchOpen Access04 Jan 2018
Molecular Psychiatry

Volume: 23, P: 2192-2208
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia

Alessandro Gialluisi
Till F. M. Andlauer
Gerd Schulte-Körne
ResearchOpen Access11 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-15
“DNA Methylation signatures in panic disorder”

Stella Iurato
Tania Carrillo-Roa
Angelika Erhardt
ResearchOpen Access18 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-10
Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models

Riya Paul
Till. F. M. Andlauer
Philipp G. Sämann
ResearchOpen Access05 Aug 2019
Translational Psychiatry

Volume: 9, P: 1-15
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Andreas J. Forstner
Swapnil Awasthi
Johannes Schumacher
Research11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 4179-4190
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

Tony Kam-Thong
Darina Czamara
Bertram Müller-Myhsok
Research08 Dec 2010
European Journal of Human Genetics

Volume: 19, P: 465-471
Epigenetic signature of very low birth weight in young adult life

Juho Kuula
Darina Czamara
Eero Kajantie
ResearchOpen Access19 Jun 2024
Pediatric Research

Volume: 97, P: 229-238
Genome-Wide Association Study of Antidepressant Treatment-Emergent Suicidal Ideation

Andreas Menke
Katharina Domschke
Elisabeth B Binder
Research26 Oct 2011
Neuropsychopharmacology

Volume: 37, P: 797-807
A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults

K U Ludwig
P Sämann
D Czamara
ResearchOpen Access19 Feb 2013
Translational Psychiatry

Volume: 3, P: e229

Search

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Dilution of candidates: the case of iron-related genes in restless legs syndrome

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

A mega-analysis of genome-wide association studies for major depressive disorder

Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Toll-like receptor 4 methylation grade is linked to depressive symptom severity

Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

FoxO1, A2M, and TGF-β1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses

Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia

“DNA Methylation signatures in panic disorder”

Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

Epigenetic signature of very low birth weight in young adult life

Genome-Wide Association Study of Antidepressant Treatment-Emergent Suicidal Ideation

A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults

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