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Showing 1–9 of 9 results
Advanced filters: Author: David Breitbach Clear advanced filters

  • Oncolytic viruses are under development for tumor treatment. David Kirn and colleagues now report their results of a randomized phase 2 dose-finding trial of JX-594, an oncolytic immunotherapeutic vaccinia virus, in patients with advanced hepatocellular carcinoma. The study shows that high-dose JX-594 was associated with significantly improved overall survival and induced radiographic responses and antitumor immunity.

    • Jeong Heo
    • Tony Reid
    • David H Kirn
    Research
    Nature Medicine
    Volume: 19, P: 329-336

  • Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.

    • Dawn M. Dudley
    • Matthew T. Aliota
    • David H. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • A new method to form Bose–Einstein condensates of quasiparticles based on the rapid decrease in the phonon temperature was proposed and shown experimentally.

    • Michael Schneider
    • Thomas Brächer
    • Andrii V. Chumak
    Research
    Nature Nanotechnology
    Volume: 15, P: 457-461

  • Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

    • Christina M. Newman
    • Dawn M. Dudley
    • Thomas C. Friedrich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

    • Dawn M. Dudley
    • Christina M. Newman
    • Matthew T. Aliota
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Oncolytic viruses were originally designed as tumour-lysing therapeutics. However, they also initiate systemic antitumour immune responses. Can these viruses be exploited to enhance antitumour immune responses, and how might they be combined with other cancer immunotherapies?

    • Brian D. Lichty
    • Caroline J. Breitbach
    • John C. Bell
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 559-567