Nature Search

Suckling mouse cataract agent is a helical wall-free prokaryote (spiroplasma) pathogenic for vertebrates

JOSEPH G. TULLY
ROBERT F. WHITCOMB
H. FRED CLARK
Research15 Jan 1976
Nature

Volume: 259, P: 117-120
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb
Michael C. Gorry
Garth D. Ehrlich
Research01 Oct 1996
Nature Genetics

Volume: 14, P: 141-145
What is personalized medicine and what should it replace?

Personalized medicine is a new framework for medical care that involves modelling and simulation of a disease on the basis of underlying mechanisms. In this article, David Whitcomb uses chronic pancreatitis and an example to outline the limitations of the 20^thcentury framework for medical care and examines the advantages of personalized medicine.

David C. Whitcomb
Reviews22 May 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 418-424
Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Jonathan D. Pollock
David A. Williams
Mary C. Dinauer
Research01 Feb 1995
Nature Genetics

Volume: 9, P: 202-209
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

Ellis J. Neufeld
David G. Skalnik
Stuart H. Orkin
Research01 Apr 1992
Nature Genetics

Volume: 1, P: 50-55
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

André Larochelle
Josef Vormoor
John E. Dick
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1329-1337
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

David C Whitcomb
Jessica LaRusch
Bernie Devlin
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1349-1354
Biopsy and personalized medicine

David C. Whitcomb
Adrian V. Lee
Correspondence02 Oct 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 683
Cytoskeletal regulation of concanavalin A capping in pulmonary alveolar macrophages

DAVID A. WILLIAMS
LAURENCE A. BOXER
ROBERT L. BAEHNER
Research19 May 1977
Nature

Volume: 267, P: 255-257
The Effect of Amniotic Fluid Aspiration on Pulmonary Function in the Adult and Newborn Rabbit

James H Jose
Richard L Schreiner
Mervyn Cohen
Research01 Dec 1983
Pediatric Research

Volume: 17, P: 976-981
The past 10 years of gastroenterology and hepatology—reflections and predictions

Five of our Advisory Board Members—international experts across different subspecialties—reflect on the progress and frustrations of the past 10 years in gastroenterology and hepatology. They also comment on where effort and money should be invested now, as well as their predictions for progress in the next 10 years.

Scott L. Friedman
Eamonn M. M. Quigley
David C. Whitcomb
Reviews07 Oct 2014
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 692-700
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate

David M. J. Martindill
Catherine A. Risebro
Paul R. Riley
Research23 Sept 2007
Nature Cell Biology

Volume: 9, P: 1131-1141
The Chronically Reserpinized Rat as a Possible Animal Model for Cystic Fibrosis. IV. The Protein Composition of Pulmonary Lavage Fluid

Frederick E Thompson
David O Quissell
J R Martinez
Research01 Jun 1976
Pediatric Research

Volume: 10, P: 632-635
Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type

Lesley M. Loomes
Kei-ichi Uemura
Ten Feizi
Research09 Feb 1984
Nature

Volume: 307, P: 560-563
A deep catalogue of protein-coding variation in 983,578 individuals

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
ResearchOpen Access20 May 2024
Nature

Volume: 631, P: 583-592
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial

The potential of evinacumab, a monoclonal antibody targeting angiopoietin-like 3, for reducing triglyceride levels was tested in patients with severe hypertriglyceridemia due to differing genetic etiologies.

Robert S. Rosenson
Daniel Gaudet
Daniel J. Rader
ResearchOpen Access06 Mar 2023
Nature Medicine

Volume: 29, P: 729-737
Molecular Analysis of the Hematopoietic Microenvironment

David A Williams
Research01 Nov 1994
Pediatric Research

Volume: 36, P: 557-560
GASTRIC SECRETORY MATURATION OF PRETERM INFANTS

David Clarke
Paul E Hyman
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 193
Does anticipation exist in familial pancreatic cancer?

Julia B Greer
David C Whitcomb
Comments & Opinion01 Jul 2006
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 3, P: 374-375
COOLEY'S ANEMIA: TRANSFUSIONS REGIMEN AND IPON BALANCE

Michael Weiner
Margaret Karpatkin
Sergfio Piomeill
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 483
Mechanisms of Disease: advances in understanding the mechanisms leading to chronic pancreatitis

At present there is no cure for chronic pancreatitis—a progressive condition that culminates in the destruction of the pancreas. Recent advances in genetic and immunologic research have spawned new insights into the mechanisms underlying chronic pancreatitis, and new models are helping us understand associated risk factors and etiologies.

David C Whitcomb
Reviews01 Nov 2004
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 1, P: 46-52
Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
Amendments and CorrectionsOpen Access08 Jan 2025
Nature

Volume: 637, P: E26
Absorption of Calcium and Magnesium from Fortified Human Milk by Very Low Birth Weight Infants

Ya-Mei Liu
Patricia Neal
James Lemons
Research01 May 1989
Pediatric Research

Volume: 25, P: 496-502
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

Daniel J. Whitcomb
Ellen L. Hogg
Kwangwook Cho
ResearchOpen Access09 Jun 2015
Scientific Reports

Volume: 5, P: 1-12
The role of alcohol and smoking in pancreatitis

Chronic alcohol use has been linked to pancreatitis for over a century, but its role in the disease has only been recently elucidated. This Review focuses on what is known from animal models and association studies conducted in humans about the relationship between alcohol consumption, smoking, and chronic pancreatitis. The authors discuss the incidence, pathogenesis and etiology of pancreatitis as well as mechanisms of disease.

Dhiraj Yadav
David C. Whitcomb
Reviews02 Feb 2010
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 131-145
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Beth A Firulli
Dayana Krawchuk
Anthony B Firulli
Research27 Feb 2005
Nature Genetics

Volume: 37, P: 373-381
A randomized double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in children and adolescents with autism spectrum disorder

Christopher J. McDougle
Robyn P. Thom
David J. Posey
Research03 Mar 2022
Neuropsychopharmacology

Volume: 47, P: 1263-1270
Chronic pancreatitis

Chronic pancreatitis is characterized by chronic inflammation of the pancreas that results in progressive scarring of the pancreatic tissue, pain and pancreatic gland dysfunction. In this Primer, Kleeff et al. describe the current understanding of chronic pancreatitis and its complications.

Jorg Kleeff
David C. Whitcomb
John P. Neoptolemos
Reviews07 Sept 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-18
Hereditary, familial, and idiopathic chronic pancreatitis are not associated with polymorphisms in the tumor necrosis factor α (TNF-α) promoter region or the TNF receptor 1 (TNFR1) gene

Alexander Schneider
Kay Pogue-Geile
David C Whitcomb
Research01 Mar 2003
Genetics in Medicine

Volume: 5, P: 120-125
FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines

Joshua I. Warrick
Vonn Walter
David J. DeGraff
ResearchOpen Access07 Dec 2016
Scientific Reports

Volume: 6, P: 1-15
Atrial Fibrillation Detection from Wrist Photoplethysmography Signals Using Smartwatches

Syed Khairul Bashar
Dong Han
Ki H. Chon
ResearchOpen Access21 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target

Jonas J. Staudacher
Cemal Yazici
Barbara Jung
ResearchOpen Access06 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity

Ruxandra Bachmann-Gagescu
Heather C Mefford
Karen D Tsuchiya
Research30 Aug 2010
Genetics in Medicine

Volume: 12, P: 641-647
Positive cell-free fetal DNA testing for trisomy 13 reveals confined placental mosaicism

April L. Hall
Holli M. Drendel
Gail H. Vance
Research14 Mar 2013
Genetics in Medicine

Volume: 15, P: 729-732

Search

Suckling mouse cataract agent is a helical wall-free prokaryote (spiroplasma) pathogenic for vertebrates

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

What is personalized medicine and what should it replace?

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Biopsy and personalized medicine

Cytoskeletal regulation of concanavalin A capping in pulmonary alveolar macrophages

The Effect of Amniotic Fluid Aspiration on Pulmonary Function in the Adult and Newborn Rabbit

The past 10 years of gastroenterology and hepatology—reflections and predictions

Nucleolar release of Hand1 acts as a molecular switch to determine cell fate

The Chronically Reserpinized Rat as a Possible Animal Model for Cystic Fibrosis. IV. The Protein Composition of Pulmonary Lavage Fluid

Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type

A deep catalogue of protein-coding variation in 983,578 individuals

Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial

Molecular Analysis of the Hematopoietic Microenvironment

GASTRIC SECRETORY MATURATION OF PRETERM INFANTS

Does anticipation exist in familial pancreatic cancer?

COOLEY'S ANEMIA: TRANSFUSIONS REGIMEN AND IPON BALANCE

Mechanisms of Disease: advances in understanding the mechanisms leading to chronic pancreatitis

Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

Absorption of Calcium and Magnesium from Fortified Human Milk by Very Low Birth Weight Infants

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

The role of alcohol and smoking in pancreatitis

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

A randomized double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in children and adolescents with autism spectrum disorder

Chronic pancreatitis

Hereditary, familial, and idiopathic chronic pancreatitis are not associated with polymorphisms in the tumor necrosis factor α (TNF-α) promoter region or the TNF receptor 1 (TNFR1) gene

FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines

Atrial Fibrillation Detection from Wrist Photoplethysmography Signals Using Smartwatches

Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target

Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity

Positive cell-free fetal DNA testing for trisomy 13 reveals confined placental mosaicism

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