Nature Search

Author Correction: Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Stroke genetics informs drug discovery and risk prediction across ancestries

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Aniket Mishra
Rainer Malik
Stephanie Debette
ResearchOpen Access30 Sept 2022
Nature

Volume: 611, P: 115-123
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13⁺ T_PH/T_FH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Calvin Law
Vanessa Sue Wacleche
Deepak A. Rao
Research10 Jul 2024
Nature

Volume: 631, P: 857-866
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Erratum: Targets of homeotic gene control in Drosophila

Alex P. Gould
Jenny J. Brookman
Robert A. H. White
Amendments and Corrections06 Dec 1990
Nature

Volume: 348, P: 560
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Author Correction: Patterns of somatic structural variation in human cancer genomes

Yilong Li
Nicola D. Roberts
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E38
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1076
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Rare variant contribution to the heritability of coronary artery disease

Whole genome sequences enable discovery of rare variants which may help to explain the heritability of common diseases. Here the authors find that ultra-rare variants explain ~50% of coronary artery disease (CAD) heritability and highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.

Ghislain Rocheleau
Shoa L. Clarke
Ron Do
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-13
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Branden Moriarity, David Largaespada and colleagues report a Sleeping Beauty forward genetic screen in mice that identifies candidate genes and pathways for osteosarcoma tumor development and progression. They identify sites specifically associated with tumorigenesis and metastasis and find that several candidate oncogenes are involved in axon guidance.

Branden S Moriarity
George M Otto
David A Largaespada
Research11 May 2015
Nature Genetics

Volume: 47, P: 615-624
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

Eric Rahrmann and colleagues performed a transposon-based somatic mutagenesis screen for genes involved in malignant peripheral nerve sheath tumors (MPNSTs). They identified many recurrent transposon insertions and nominate Foxr2 as a new oncogene in MPNSTs.

Eric P Rahrmann
Adrienne L Watson
David A Largaespada
Research19 May 2013
Nature Genetics

Volume: 45, P: 756-766
A reference map of the human binary protein interactome

A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

Katja Luck
Dae-Kyum Kim
Michael A. Calderwood
Research08 Apr 2020
Nature

Volume: 580, P: 402-408
Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice

This work applies high-resolution fMRI with real-time pupillometry in 5xFAD transgenic mice to verify pupillary biomarkers of Alzheimer’s disease (AD). In particular, the pupil-driven fMRI maps identify dysfunction of neuromodulatory pathways affected by AD degeneration.

Xiaochen Liu
David Hike
Xin Yu
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-13
Dual expression of λ genes in the MOPC-315 plasmacytoma

Alfred L. M. Bothwell
Michael Paskind
David Baltimore
Research01 Mar 1981
Nature

Volume: 290, P: 65-67
Multiple origins of the spinocerebellar ataxia 7 (SCA7) mutation revealed by linkage disequilibrium studies with closely flanking markers, including an intragenic polymorphism (G³¹⁴⁵TG/A³¹⁴⁵TG)

G Stevanin
G David
A Brice
Research08 Dec 1999
European Journal of Human Genetics

Volume: 7, P: 889-896
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Margaret Sunitha Selvaraj
Xihao Li
Pradeep Natarajan
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Yiqun Zhang
Fengju Chen
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Comparison of 10 biometric formulas in combined phacovitrectomy for different underlying retinal pathology

Eleftherios Chatzimichail
David L. Cooke
Efstathios Vounotrypidis
ResearchOpen Access17 Apr 2025
Scientific Reports

Volume: 15, P: 1-8
Variants in the WDR44 WD40-repeat ___domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

A vesicle trafficking Rab11 effector switch is important for ciliogenesis. Here, the authors report a ciliopathy-related disorder caused by variants in WDR44, a Rab11 effector. WDR44 variants show higher affinity for Rab11 and can impair ciliogenesis.

Andrea Accogli
Saurabh Shakya
Christopher J. Westlake
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-20
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures

Daniel H. Mathalon
Spero Nicholas
Gregory A. Light
ResearchOpen Access06 Jun 2025
Schizophrenia

Volume: 11, P: 1-18
Antibody and HIV-1 gpl20 recognition of CD4 undermines the concept of mimicry between antibodies and receptors

Simon J. Davis
Gérard A. Schockmel
Alan F. Williams
Research02 Jul 1992
Nature

Volume: 358, P: 76-79
The role of RhoA in tissue polarity and Frizzled signalling

David I. Strutt
Ursula Weber
Marek Mlodzik
Research15 May 1997
Nature

Volume: 387, P: 292-295
Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

Aurélie Wiedemann
Edouard Lhomme
Huanying Zhou
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Combined inhibition of KRAS^G12C and mTORC1 kinase is synergistic in non-small cell lung cancer

Despite the development of inhibitors targeting active GTP-bound (ON) KRAS(G12C) for the treatment of KRAS G12C-driven non-small cell lung cancer (NSCLC), resistance remains an issue. Here, the authors show that despite inhibition of KRAS G12C ON, there is residual mTOR activity driving resistance, which was successfully targeted by combining with a selective mTOR inhibitor.

Hidenori Kitai
Philip H. Choi
Neal Rosen
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

Natasha J. Caplen
Eric W.F.W. Alton
Duncan M. Geddes
Research01 Jan 1995
Nature Medicine

Volume: 1, P: 39-46
Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder

In isolated REM sleep behavior disorder, a prodromal syndrome often leading to parkinsonism, expression levels for an abnormal disease network increase steadily before diagnosis. The measure can help evaluate phenoconversion risk in these patients.

Chris C. Tang
Yoshikazu Nakano
David Eidelberg
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Grandmaster level in StarCraft II using multi-agent reinforcement learning

AlphaStar uses a multi-agent reinforcement learning algorithm and has reached Grandmaster level, ranking among the top 0.2% of human players for the real-time strategy game StarCraft II.

Oriol Vinyals
Igor Babuschkin
David Silver
Research30 Oct 2019
Nature

Volume: 575, P: 350-354
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning

Protein kinase NEK8 is important for cilliary function, but the mechanism by which it acts is unknown. Czarnecki et al. identify the cilliary protein ANKS6 as a target and crucial activator of NEK8 and describe the importance of this protein interaction in embryonic development and organogenesis.

Peter G. Czarnecki
George C. Gabriel
Jagesh V. Shah
Research20 Jan 2015
Nature Communications

Volume: 6, P: 1-13
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Clonal haematopoiesis and risk of chronic liver disease

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Research12 Apr 2023
Nature

Volume: 616, P: 747-754
Biomaterials in cellular agriculture and plant-based foods for the future

Biomaterials have a crucial role in the development of future foods, particularly in cellular agriculture and plant-based systems. This Review addresses the current status and future requirements of biomaterials for future foods, addressing key aspects such as structure, nutrition, safety, sensory attributes, sustainability and consumer preferences.

Edward B. Gordon
Inyoung Choi
David L. Kaplan
Reviews07 May 2025
Nature Reviews Materials

Volume: 10, P: 500-518
In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits

Minimally invasive cellular-level target-specific neuromodulation is needed to decipher brain function and neural circuitry. Here nano-magnetogenetics using magnetic force actuating nanoparticles has been reported, enabling wireless and remote stimulation of targeted deep brain neurons in freely behaving animals.

Seo-Hyun Choi
Jihye Shin
Jinwoo Cheon
Research02 Jul 2024
Nature Nanotechnology

Volume: 19, P: 1333-1343
Hypoxic Injury to Developing Glial Cells: Protective Effect of High Glucose

David J Callahan
Michael J Engle
Joseph J Volpe
Research01 Feb 1990
Pediatric Research

Volume: 27, P: 186-190
Crunch time for Korea's cloners

A team in Seoul has stolen a march with its work towards human therapeutic cloning. The researchers have been fêted, but an ethical controversy may threaten their work. David Cyranoski investigates.

David Cyranoski
News06 May 2004
Nature

Volume: 429, P: 12-14
A portrait of the Higgs boson by the CMS experiment ten years after the discovery

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A. Tumasyan
W. Adam
A. Zhokin
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 60-68
Author Correction: Pan-cancer analysis of whole genomes

Lauri A. Aaltonen
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E39
Author Correction: The landscape of viral associations in human cancers

Marc Zapatka
Ivan Borozan
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1077
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma

Savita Bhalla
Sriram Balasubramanian
Andrew Evens
ResearchOpen Access12 Jul 2008
Nature Precedings

P: 1
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Author Correction: Genomic basis for RNA alterations in cancer

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E37
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

Yuan Yuan
Young Seok Ju
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1078
A hole-selective hybrid TiO₂ layer for stable and low-cost photoanodes in solar water oxidation

This study presents a hybrid polyethyleneimine/TiO₂ protective layer as a low-cost photoanode for solar water oxidation. The hybrid layer facilitates hole transfer from the photoanode and results in high photostability over 400 hours.

Sanghyun Bae
Thomas Moehl
S. David Tilley
ResearchOpen Access01 Nov 2024
Nature Communications

Volume: 15, P: 1-9
Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Sangwook Oh
Xuming Mao
Aimee S. Payne
Amendments and CorrectionsOpen Access14 Nov 2024
Nature Biotechnology

Volume: 42, P: 1923

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