Vesicoureteral reflux (VUR) a common urological anomaly in children, and can result in reflux-associated nephropathy, which is a major cause of childhood hypertension and chronic renal failure. In this Review, the authors discuss the pathogenesis of VUR, and consider genetic syndromes and gene loci that have been associated with the disorder.
- Prem Puri
- Jan-Hendrik Gosemann
- David E. Barton