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Showing 1–23 of 23 results
Advanced filters: Author: David Kimelman Clear advanced filters

  • The connection between the molecular and physical control of embryonic tissues remains unclear. Here, the authors connect genetic mutations to changes in the physical state of posterior tissues during axis elongation, revealing a key role for dorsal tissues.

    • Georgina A. Stooke-Vaughan
    • Sangwoo Kim
    • Otger Campàs
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • We present the ‘zebrafish single-cell atlas of perturbed embryos’, single-cell trancriptomic data of developing zebrafish embryos across various timepoints and with genetic perturbations.

    • Lauren M. Saunders
    • Sanjay R. Srivatsan
    • Cole Trapnell
    ResearchOpen Access
    Nature
    Volume: 623, P: 782-791

    • David Jones
    News & Views
    Nature
    Volume: 358, P: 112

  • This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

    • Gil A. McVean
    • David M. Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 491, P: 56-65

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • 1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

    • Olivier Delaneau
    • Jonathan Marchini
    • Leena Peltonenz
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • The putative tumour suppressor LKB1/XEEK1 (Xenopus egg and embryo kinase 1) has been implicated in many cellular processes and signalling pathways. Now, XEEK1 is found to exist in a complex with GSK3 (glycogen synthase kinase 3) and protein kinase C ζ (PKCζ), resulting in increased Wnt signal transduction during embryonic development. This discovery positions XEEK1 as a potential intersection point for crosstalk between Wnt and other pathways.

    • Wilson K. Clements
    • David Kimelman
    News & Views
    Nature Cell Biology
    Volume: 5, P: 861-863

  • Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.

    • David Kimelman
    • Daniel P. Szeto
    News & Views
    Nature Cell Biology
    Volume: 8, P: 305-307

  • Although major molecular players with a role in mesoderm induction have been identified, high-throughput approaches are beginning to yield data that will help us to understand how the embryo integrates and processes the various signals during mesoderm induction.

    • David Kimelman
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 360-372

  • BMP signalling is required for the emergence of haematopoietic stem cells (HSCs) from the zebrafish dorsal aorta. Here the authors show that FGF signalling negatively regulates HSC emergence by downregulating BMP activity in the zebrafish subaortic mesenchyme and upregulating the expression of BMP antagonists in the somite.

    • Claire Pouget
    • Tessa Peterkin
    • Roger Patient
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Studies of the establishment of definitive haematopoiesis in various model organisms have identified signalling requirements for the specification of haematopoietic stem cells (HSCs); this information could inform attempts to generate HSCsin vitrofor therapeutic use.

    • Wilson K. Clements
    • David Traver
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 336-348

  • Proper control of intercellular communication through the Wnt signaling pathway is of critical importance for many aspects of biology, including head formation during vertebrate embryogenesis. A recent Cell paper describes the discovery of a novel protein, TIKI, which controls head size through a surprising new mechanism of Wnt antagonism.

    • Cortney M Bouldin
    • David Kimelman
    Research Highlights
    Cell Research
    Volume: 22, P: 1621-1623