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Showing 1–50 of 71 results

Advanced filters: Author: David L. Rigby Clear advanced filters

The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H–2D^d, not Qa/Tla

Paul M. Brickell
David S. Latchman
Peter W. J. Rigby
Research11 Jul 1985
Nature

Volume: 316, P: 162-163
Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

Paul M. Brickell
David S. Latchman
Peter W. J. Rigby
Research22 Dec 1983
Nature

Volume: 306, P: 756-760
Cytocidal Activity of Plant Auxin Analogues Against the Ehrlich Ascites Carcinoma

ROBERT D. SCHULTZ
DAVID NORMAN
Research17 Apr 1965
Nature

Volume: 206, P: 276-279
A fragment of the SV40 large T-antigen gene transforms

Christine E. Clayton
David Murphy
Peter W. J. Rigby
Research01 Sept 1982
Nature

Volume: 299, P: 59-61
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Stephen M. Hedrick
David I. Cohen
Mark M. Davis
Research08 Mar 1984
Nature

Volume: 308, P: 149-153
Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution

David C. Page
Mary E. Harper
David Botstein
Research13 Sept 1984
Nature

Volume: 311, P: 119-123
A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

Michael C. Carroll
R. Duncan Campbell
Rodney R. Porter
Research19 Jan 1984
Nature

Volume: 307, P: 237-241
Mitochondrial and chloroplast genomes of maize have a 12-kilobase DNA sequence in common

David B. Stern
David M. Lonsdale
Research21 Oct 1982
Nature

Volume: 299, P: 698-702
Extrachromosomal circular copies of the eukaryotic transposable element copia in cultured Drosophila cells

Andrew J. Flavell
David Ish-Horowicz
Research13 Aug 1981
Nature

Volume: 292, P: 591-595
Linearization of maize mitochondrial chromosomes by recombination with linear episomes

Christopher L. Schardl
David M. Lonsdale
Kathryn R. Rose
Research26 Jul 1984
Nature

Volume: 310, P: 292-296
Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line

Prasanta R. Chakraborty
Nelson Ruiz-Opazo
David A. Shafritz
Research31 Jul 1980
Nature

Volume: 286, P: 531-533
Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

David A. Williams
Ihor R. Lemischka
Richard C. Mulligan
Research09 Aug 1984
Nature

Volume: 310, P: 476-480
Immunological Investigation of Human Growth Hormone

DAVID R. HADDEN
Research10 Nov 1962
Nature

Volume: 196, P: 581-582
Complex economic activities concentrate in large cities

Balland et al. use data on scientific papers, patents, employment and GDP for 353 metropolitan areas in the United States to show that economic complexity drives the spatial concentration of productive activities in large cities.

Pierre-Alexandre Balland
Cristian Jara-Figueroa
César A. Hidalgo
Research13 Jan 2020
Nature Human Behaviour

Volume: 4, P: 248-254
Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes

Alfred Nordheim
Mary Lou Pardue
Alexander Rich
Research03 Dec 1981
Nature

Volume: 294, P: 417-422
Facile transition of poly[d(TG)·d(CA)] into a left-handed helix in physiological conditions

David B. Haniford
David E. Pulleyblank
Research14 Apr 1983
Nature

Volume: 302, P: 632-634
Protein synthesis required to anchor a mutant p⁵³ protein which is temperature-sensitive for nuclear transport

Julian V. Cannon
David P. Lane
Research28 Feb 1991
Nature

Volume: 349, P: 802-806
Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes

David A. Campbell
Deborah A. Thornton
John C. Boothroyd
Research27 Sept 1984
Nature

Volume: 311, P: 350-355
A novel HLA class II molecule (DRα–sDQβ) created by mismatched isotype pairing

Vincent Lotteau
Luc Teyton
Dominique Charron
Research24 Sept 1987
Nature

Volume: 329, P: 339-341
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

Igor B. Roninson
Herbert T. Abelson
Alexander Varshavsky
Research14 Jun 1984
Nature

Volume: 309, P: 626-628
Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

Jeffrey A. Drebin
David F. Stern
Mark I. Greene
Research06 Dec 1984
Nature

Volume: 312, P: 545-548
Expression and regulation of human low-density lipoprotein receptors in Chinese hamster ovary cells

Robert D. Sege
Karen Kozarsky
Monty Krieger
Research23 Feb 1984
Nature

Volume: 307, P: 742-745
One-quarter of freshwater fauna threatened with extinction

A global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.

Catherine A. Sayer
Eresha Fernando
William R. T. Darwall
ResearchOpen Access08 Jan 2025
Nature

Volume: 638, P: 138-145
Two steroid 21-hydroxylase genes are located in the murine S region

Perrin C. White
David D. Chaplin
J. G. Seidman
Research29 Nov 1984
Nature

Volume: 312, P: 465-467
LexA protein inhibits transcription of the E. coli uvrA gene in vitro

Aziz Sancar
Gwendolyn B. Sancar
David W. Mount
Research01 Jul 1982
Nature

Volume: 298, P: 96-98
Xenobiotic conjugation: a novel role for bile acids

Gary B. Quistad
Luana E. Staiger
David A. Schooley
Research01 Apr 1982
Nature

Volume: 296, P: 462-464
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

Raymond J. Deshaies
Sylvia L. Sanders
Randy Schekman
Research28 Feb 1991
Nature

Volume: 349, P: 806-808
The insulin gene is located on chromosome 11 in humans

David Owerbach
Graeme I. Bell
Thomas B. Shows
Research03 Jul 1980
Nature

Volume: 286, P: 82-84
In vivo consequences of plasmid topology

David M. J. Lilley
Research23 Jul 1981
Nature

Volume: 292, P: 380-382
Spatial variations in aromatic hydrocarbon emission in a dust-rich galaxy

We present James Webb Space Telescope observations that detect the 3.3 μm polycyclic aromatic hydrocarbon feature in a galaxy observed less than 1.5 billion years after the Big Bang.

Justin S. Spilker
Kedar A. Phadke
Katherine E. Whitaker
Research05 Jun 2023
Nature

Volume: 618, P: 708-711
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

Michael Egholm
Ole Buchardt
Peter E. Nielsen
Research07 Oct 1993
Nature

Volume: 365, P: 566-568
Author Correction: Global increase of ozone-depleting chlorofluorocarbons from 2010 to 2020

Luke M. Western
Martin K. Vollmer
Johannes C. Laube
Amendments and Corrections18 May 2023
Nature Geoscience

Volume: 16, P: 546
Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia

Christine M. Morris
Anthony E. Reeve
David C. Heaton
Research20 Mar 1986
Nature

Volume: 320, P: 281-283
Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34^cdc2 restriction

David L. Brautigan
John Sunwoo
Ned J. C. Lamb
Research01 Mar 1990
Nature

Volume: 344, P: 74-78
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

RH5, which is part of the trimeric RCR-complex essential for invasion, is a vaccine candidate for malaria. Here, Williams et al. show that monoclonal antibodies targeting each of the three proteins in the RCR-complex can work together to more effectively block the invasion of red blood cells by Plasmodium falciparum and design a combination vaccine candidate.

Barnabas G. Williams
Lloyd D. W. King
Simon J. Draper
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
Travelling light

David Jones
News & Views28 Jul 1994
Nature

Volume: 370, P: 254
Molecules and man

David Weatherall
Books & Arts27 Aug 1987
Nature

Volume: 328, P: 771-772
An automated 13.5 hour system for scalable diagnosis and acute management guidance for genetic diseases

Rapid diagnosis and implementation of treatments is crucial in many genetic conditions. Here the authors describe Genome-to-Treatment, a virtual disease management system that can achieve a rapid diagnosis by expedited whole genome sequencing in 13.5 hours and provide guidance to clinicians for possible therapies.

Mallory J. Owen
Sebastien Lefebvre
Stephen F. Kingsmore
ResearchOpen Access26 Jul 2022
Nature Communications

Volume: 13, P: 1-14
Global increase of ozone-depleting chlorofluorocarbons from 2010 to 2020

Levels of five chlorofluorocarbons rose in the atmosphere from 2010 to 2020 despite their production being banned by the Montreal Protocol, probably arising as by-products of hydrofluorocarbon production, according to analysis of abundance and emissions data.

Luke M. Western
Martin K. Vollmer
Johannes C. Laube
Research03 Apr 2023
Nature Geoscience

Volume: 16, P: 309-313
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-13
The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I terpene cyclases.

Stephen A. Marshall
Karl A. P. Payne
David Leys
ResearchOpen Access29 May 2019
Nature Communications

Volume: 10, P: 1-10
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription

The formation of blood and lymph vessels after injury requires precise temporal coordination. Here, the authors show that the small GTPase RhoB induces angiogenesis but inhibits lymphangiogenesis in response to dermal wounding by activating different sets of genes in blood vessels and lymphatic endothelial cells.

Damien Gerald
Irit Adini
Laura E. Benjamin
ResearchOpen Access27 Nov 2013
Nature Communications

Volume: 4, P: 1-15
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

In patients with DNA damage response-deficient solid tumors, the oral ATR kinase inhibitor camonsertib was well tolerated; a recommended phase 2 dose was identified; and encouraging anti-tumor activity was observed, with the highest response rate observed in patients with ovarian cancer.

Timothy A. Yap
Elisa Fontana
Ezra Rosen
ResearchOpen Access05 Jun 2023
Nature Medicine

Volume: 29, P: 1400-1411
Prognostic significance of allelic losses in primary melanoma

Eugene Healy
Christine Belgaid
Jonathan L Rees
Research15 May 1998
Oncogene

Volume: 16, P: 2213-2218
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

Ubiquinone is an essential component of electron transfer chains found both in bacteria and in mitochondria; the bacterial enzyme UbiX involved in ubiquinone biosynthesis is a flavin prenyltransferase, and the flavin-derived cofactor synthesized by UbiX is used by the UbiD decarboxylase in the ubiquinone biosynthetic pathway.

Mark D. White
Karl A. P. Payne
David Leys
Research17 Jun 2015
Nature

Volume: 522, P: 502-506
An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Characterization of the first Per-ARNT-Sim enzyme, a haem-dependent oxidative N-demethylase.

Mary Ortmayer
Pierre Lafite
David Leys
Research16 Nov 2016
Nature

Volume: 539, P: 593-597
Targeting Gene Expression to the Wool Follicle in Transgenic Sheep

Sami Damak
Nigel P. Jay
David W. Bullock
Research01 Feb 1996
Bio/Technology

Volume: 14, P: 181-184

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