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SPIRIT 2025 statement: updated guideline for protocols of randomized trials

SPIRIT 2025 provides updated guidance to authors, reviewers and editors, when preparing clinical trial protocols to enhance their transparency and completeness.

An-Wen Chan
Isabelle Boutron
Asbjørn Hróbjartsson
Reviews29 Apr 2025
Nature Medicine

Volume: 31, P: 1784-1792
CONSORT 2025 statement: updated guideline for reporting randomized trials

CONSORT 2025 provides updated guidance to authors, reviewers and editors, when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent

Sally Hopewell
An-Wen Chan
Isabelle Boutron
Reviews15 Apr 2025
Nature Medicine

Volume: 31, P: 1776-1783
Stop this waste of people, animals and money

Predatory journals have shoddy reporting and include papers from wealthy nations, find David Moher, Larissa Shamseer, Kelly Cobey and colleagues.

David Moher
Larissa Shamseer
Hedyeh Ziai
Comments & Opinion07 Sept 2017
Nature

Volume: 549, P: 23-25
Concordance of randomised controlled trials for artificial intelligence interventions with the CONSORT-AI reporting guidelines

The CONSORT-AI extension was developed to provide specific guidance for randomised controlled trials involving Artificial Intelligence (AI) interventions. Here, the authors show that since publication of CONSORT-AI, several AI-specific considerations remain systematically underreported.

Alexander P. L. Martindale
Carrie D. Llewellyn
Xiaoxuan Liu
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Lessons from the major studies in COPD: problems and pitfalls in translating research evidence into practice

David MG Halpina
Research29 Mar 2010
Primary Care Respiratory Journal

Volume: 19, P: 170-179
Author Correction: Concordance of randomised controlled trials for artificial intelligence interventions with the CONSORT-AI reporting guidelines

Alexander P. L. Martindale
Carrie D. Llewellyn
Xiaoxuan Liu
Amendments and CorrectionsOpen Access29 Jul 2024
Nature Communications

Volume: 15, P: 1
Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

Samantha Cruz Rivera
Xiaoxuan Liu
Samuel Rowley
ReviewsOpen Access09 Sept 2020
Nature Medicine

Volume: 26, P: 1351-1363
Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

Xiaoxuan Liu
Samantha Cruz Rivera
Samuel Rowley
ReviewsOpen Access09 Sept 2020
Nature Medicine

Volume: 26, P: 1364-1374
Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy

Jeffery A Lieberman
Joel Greenhouse
Martin B Keller
Reviews12 Jan 2005
Neuropsychopharmacology

Volume: 30, P: 445-460
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with increased mortality, and there was no benefit from chloroquine.

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
ResearchOpen Access15 Apr 2021
Nature Communications

Volume: 12, P: 1-13
Predatory journals: no definition, no defence

Leading scholars and publishers from ten countries have agreed a definition of predatory publishing that can protect scholarship. It took 12 hours of discussion, 18 questions and 3 rounds to reach.

Agnes Grudniewicz
David Moher
Manoj M. Lalu
Comments & Opinion11 Dec 2019
Nature

Volume: 576, P: 210-212
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Ethics methods are required as part of reporting guidelines for artificial intelligence in healthcare

Viknesh Sounderajah
Melissa D. McCradden
Ara Darzi
Correspondence22 Apr 2022
Nature Machine Intelligence

Volume: 4, P: 316-317
Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
Amendments and CorrectionsOpen Access05 Feb 2024
Nature Communications

Volume: 15, P: 1-2
Mapping the regulatory landscape for artificial intelligence in health within the European Union

Jelena Schmidt
Nienke M. Schutte
Robin van Kessel
ResearchOpen Access27 Aug 2024
npj Digital Medicine

Volume: 7, P: 1-9
Systematic reviews deserve more credit than they get

Mohammed Toseef Ansari
David Moher
Correspondence04 Apr 2013
Nature Medicine

Volume: 19, P: 395-396
Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
Developing specific reporting guidelines for diagnostic accuracy studies assessing AI interventions: The STARD-AI Steering Group

Viknesh Sounderajah
Hutan Ashrafian
Ara Darzi
Correspondence08 Jun 2020
Nature Medicine

Volume: 26, P: 807-808
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Author Correction: Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed

Xiaoxuan Liu
Samantha Cruz Rivera
Alastair K. Denniston
Amendments and Corrections12 Nov 2019
Nature Medicine

Volume: 25, P: 1948
Implementing clinical trial data sharing requires training a new generation of biomedical researchers

Data sharing enhances the value of medical research and builds trust in clinical trials, but more biomedical researchers need to be trained in these approaches, which include meta-research, data science and ethical, legal and social issues.

Ulrich Mansmann
Clara Locher
Florian Naudet
Comments & Opinion02 Feb 2023
Nature Medicine

Volume: 29, P: 298-301
An update to SPIRIT and CONSORT reporting guidelines to enhance transparency in randomized trials

Results from clinical trials can be deemed trustworthy only if they are properly conducted and their methods are fully reported. The SPIRIT and CONSORT checklists, which have improved clinical trial design, conduct and reporting, are being updated to reflect recent advances and improve the assessment of healthcare interventions.

Sally Hopewell
Isabelle Boutron
David Moher
Comments & Opinion15 Sept 2022
Nature Medicine

Volume: 28, P: 1740-1743
PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare

Giovanni E. Cacciamani
Timothy N. Chu
Andrew J. Hung
Correspondence16 Jan 2023
Nature Medicine

Volume: 29, P: 14-15
A quality assessment tool for artificial intelligence-centered diagnostic test accuracy studies: QUADAS-AI

Viknesh Sounderajah
Hutan Ashrafian
Ara Darzi
Correspondence11 Oct 2021
Nature Medicine

Volume: 27, P: 1663-1665
How stakeholders can respond to the rise of predatory journals

Predatory journals are a global and growing problem contaminating all domains of science. A coordinated response by all stakeholders (researchers, institutions, funders, regulators and patients) will be needed to stop the influence of these illegitimate journals.

Manoj Mathew Lalu
Larissa Shamseer
David Moher
Comments & Opinion04 Dec 2017
Nature Human Behaviour

Volume: 1, P: 852-855
Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis

Farhana Islam
Daniel Hain
Daniel J. Müller
ResearchOpen Access16 Jun 2022
The Pharmacogenomics Journal

Volume: 22, P: 230-240
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Subjective assessment reported by patients shows differences between single-bundle and double-bundle anterior cruciate ligament reconstruction, systematic review and meta-analysis

Antonio Maestro
Irene Herruzo
Carlos Martín-Saborido
ResearchOpen Access28 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
A mixed-methods survey and focus group study to understand researcher and clinician preferences for a Journal Transparency Tool

Jeremy Y. Ng
Henry Liu
Kelly D. Cobey
ResearchOpen Access04 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed

As artificial intelligence moves into the realm of clinical trials, consideration is needed on whether the current CONSORT and SPIRIT reporting statements are sufficient to ensure transparency.

Xiaoxuan Liu
Samantha Cruz Rivera
Alastair K. Denniston
Comments & Opinion24 Sept 2019
Nature Medicine

Volume: 25, P: 1467-1468
Variation in the colour of the keel petals in Lotus corniculatus L. 4. Morph distribution in the British Isles

Terence J Crawford
David A Jones
Research01 Oct 1988
Heredity

Volume: 61, P: 175-188
A systematic review and narrative analysis of digital speech biomarkers in Motor Neuron Disease

Molly Bowden
Emily Beswick
Suvankar Pal
ReviewsOpen Access07 Dec 2023
npj Digital Medicine

Volume: 6, P: 1-19
Research culture in biomedicine: what we learned, and what we would like to do about it

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Alexa T. McCray
David Van Vactor
Mary C. Walsh
Comments & OpinionOpen Access07 May 2024
Communications Biology

Volume: 7, P: 1-5

Search

SPIRIT 2025 statement: updated guideline for protocols of randomized trials

CONSORT 2025 statement: updated guideline for reporting randomized trials

Stop this waste of people, animals and money

Concordance of randomised controlled trials for artificial intelligence interventions with the CONSORT-AI reporting guidelines

Lessons from the major studies in COPD: problems and pitfalls in translating research evidence into practice

Author Correction: Concordance of randomised controlled trials for artificial intelligence interventions with the CONSORT-AI reporting guidelines

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Predatory journals: no definition, no defence

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Ethics methods are required as part of reporting guidelines for artificial intelligence in healthcare

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Mapping the regulatory landscape for artificial intelligence in health within the European Union

Systematic reviews deserve more credit than they get

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Developing specific reporting guidelines for diagnostic accuracy studies assessing AI interventions: The STARD-AI Steering Group

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Author Correction: Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed

Implementing clinical trial data sharing requires training a new generation of biomedical researchers

An update to SPIRIT and CONSORT reporting guidelines to enhance transparency in randomized trials

PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare

A quality assessment tool for artificial intelligence-centered diagnostic test accuracy studies: QUADAS-AI

How stakeholders can respond to the rise of predatory journals

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Subjective assessment reported by patients shows differences between single-bundle and double-bundle anterior cruciate ligament reconstruction, systematic review and meta-analysis

A mixed-methods survey and focus group study to understand researcher and clinician preferences for a Journal Transparency Tool

Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed

Variation in the colour of the keel petals in Lotus corniculatus L. 4. Morph distribution in the British Isles

A systematic review and narrative analysis of digital speech biomarkers in Motor Neuron Disease

Research culture in biomedicine: what we learned, and what we would like to do about it

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