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Showing 1–2 of 2 results
Advanced filters: Author: David Podlesainski Clear advanced filters

  • The targeted development of proteome-wide selective covalent probes remains a challenge. Here, the authors show the exploration of the natural product Sulphostin as a starting point for dipeptidyl peptidase 8 and 9 inhibitor development.

    • Leonard Sewald
    • Werner W. A. Tabak
    • Markus Kaiser
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Rare mutations in the high requirement temperature protein A1 (HTRA1) cause cerebral vasculopathy. Here, authors establish mechanistically distinct protein repair approaches to reverse the deleterious effects of pathogenic mutations interfering with the assembly and protease function of HTRA1.

    • Nathalie Beaufort
    • Linda Ingendahl
    • Martin Dichgans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18