Photodynamic therapy is a promising and effective strategy for being trialed for clinical application. However, poor targeting accumulation of traditional nanoprobes in tumor tissues has hindered its clinical use. Herein, ultra-small and highly stable Fe3O4@P-NPO/PEG-Glc@Ce6 nanoprobes were developed to improve the tumor-targeting efficiency and photodynamic therapeutic efficacy based on small size effect. The nanoprobes effectively prolong the residence time in the tumor region, reduce the accumulation in vital organs and significantly inhibit the growth of tumors in vivo. The successful application of small size effect in nanoprobes provides a new path for clinical therapies and translation in the near future.
- Ting Yin
- Qian Zhang
- Daxiang Cui
